Exosomes are well-known key mediators of intercellular communication and contribute to
various physiological and pathological processes. Their biogenesis involves four key steps …

Simple Summary Exosomes are nanometer-sized vesicles released by different cells that
are important in the normal functioning of the body. In cancer, exosomes have been found to …

Aberrant overexpression or activation of EGFR drives the development of non-small cell
lung cancer (NSCLC) and acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) by …

Background RNA binding proteins (RBPs) play a role in sorting non-coding RNAs (ncRNAs)
into exosomes. These ncRNAs, carried by exosomes, are involved in regulating various …

In addition to conventional protein secretion, dependent on the specific cleavage of signal
sequences, proteins are secreted by other processes, all together called unconventional …

Spontaneous dimerization of EGF receptors (EGFR) and dysregulation of EGFR signaling
has been associated with the development of different cancers. Under normal physiological …

In all cells, generation and release of specific vesicles are the initial steps of back-and-forth
intercellular communication. These processes are critical in normal physiology and …

EGFR cell surface density, stability, internalization, and recycling can be measured by cell
surface ELISA (cs-ELISA). Performing this experiment on ice impedes receptor …