Quercetin derivatives: Drug design, development, and biological activities, a review
SR Alizadeh, MA Ebrahimzadeh - European journal of medicinal chemistry, 2022 - Elsevier
More studies are needed to develop new drugs for problems associated with drug
resistance and unfavorable side effects. The natural flavonoid of quercetin revealed a wide …
resistance and unfavorable side effects. The natural flavonoid of quercetin revealed a wide …
[HTML][HTML] On the design principles of peptide–drug conjugates for targeted drug delivery to the malignant tumor site
Cancer is the second leading cause of death affecting nearly one in two people, and the
appearance of new cases is projected to rise by> 70% by 2030. To effectively combat the …
appearance of new cases is projected to rise by> 70% by 2030. To effectively combat the …
Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives
SR Alizadeh, N Savadkouhi… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Scientists are especially interested in polyphenols, particularly flavonoids.
Quercetin, a flavonoid, has demonstrated various therapeutic properties, such as …
Quercetin, a flavonoid, has demonstrated various therapeutic properties, such as …
Quercetin: a potential polydynamic drug
The study of natural products as potential drug leads has gained tremendous research
interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and …
interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and …
Probing the interaction of a quercetin bioconjugate with Bcl‐2 in living human cancer cells with in‐cell NMR spectroscopy
A Primikyri, N Sayyad, G Quilici, EI Vrettos, K Lim… - FEBS …, 2018 - Wiley Online Library
In‐cell NMR spectroscopy has emerged as a powerful technique for monitoring
biomolecular interactions at an atomic level inside intact cells. However, current …
biomolecular interactions at an atomic level inside intact cells. However, current …
[HTML][HTML] Ligand-observed in-tube NMR in natural products research: A review on enzymatic biotransformations, protein–ligand interactions, and in-cell NMR …
IP Gerothanassis - Arabian Journal of Chemistry, 2023 - Elsevier
Natural product-observed NMR methods have considerably expanded the potentialities for
in-tube NMR monitoring of complex enzymatic biotransformations and investigation of …
in-tube NMR monitoring of complex enzymatic biotransformations and investigation of …
Recent insights into therapeutic potential of plant-derived flavonoids against cancer
R Mohi-Ud-Din, RH Mir, S Sabreen… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Flavonoids, a class of polyphenolic secondary metabolites, are present in fruits, vegetables,
beverages such as wine and tea abundantly. Flavonoids exhibit a diverse array of …
beverages such as wine and tea abundantly. Flavonoids exhibit a diverse array of …
Research Progress on Quercetin's Biological Activity and Structural Modification Based on Its Antitumor Effects
M Guo, J Zeng, Z Sun, X Wu, Z Hu - ChemistrySelect, 2023 - Wiley Online Library
Quercetin is a naturally existing flavonoid with numerous physiological effects, including
antitumor activity. It functions as an antitumor agent by inducing apoptosis and inhibiting …
antitumor activity. It functions as an antitumor agent by inducing apoptosis and inhibiting …
Design principles governing the development of theranostic anticancer agents and their nanoformulations with photoacoustic properties
SG Kyrkou, EI Vrettos, D Gorpas, T Crook, N Syed… - Pharmaceutics, 2022 - mdpi.com
The unmet need to develop novel approaches for cancer diagnosis and treatment has led to
the evolution of theranostic agents, which usually include, in addition to the anticancer drug …
the evolution of theranostic agents, which usually include, in addition to the anticancer drug …
Development of bioactive gemcitabine-D-Lys6-GnRH prodrugs with linker-controllable drug release rate and enhanced biopharmaceutical profile
N Sayyad, EI Vrettos, T Karampelas… - European journal of …, 2019 - Elsevier
Peptide-drug conjugates have emerged as a potent approach to enhance the targeting and
pharmacokinetic profiles of drugs. However, the impact of the linker unit has not been …
pharmacokinetic profiles of drugs. However, the impact of the linker unit has not been …