Oral inhalation is the preferred route for delivery of small molecules to the lungs, because
high tissue levels can be achieved shortly after application. Biologics are mainly …

Agonist-mediated exocytosis of Weibel-Palade bodies underpins the endothelium's ability to
respond to injury or infection. Much of this important response is mediated by the major …

Rationale: Cigarette smoking is a major risk factor for lung cancer development and
progression; however, the mechanism of how cigarette smoke activates signaling pathways …

Cellular secretion depends on exocytosis of secretory vesicles and discharge of vesicle
contents. Actin and myosin are essential for pre-fusion and post-fusion stages of exocytosis …

Peptides and proteins encoded by noncanonical open reading frames (ORFs) of circRNAs
have recently been recognized to play important roles in disease progression, but the …

Objective To evaluate the effects and possible mechanisms of circular RNAs (circRNAs) on
diabetic myocardial fibrosis (DMF). Methods We used an in vivo mice model of …

Epithelial sodium channel (ENaC) is a pivotal regulator of alveolar fluid clearance in the
airway epithelium and plays a key role in the treatment of acute lung injury (ALI), which is …

Myristoylated, alanine-rich C-kinase substrate (MARCKS) is an F-actin and phospholipid
binding protein implicated in numerous cellular activities, including the regulation of …

The myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been at the
crossroads of multiple signaling pathways that govern several critical operations in normal …

Although a defective vitamin D endocrine system has been widely suspected to be
associated in SARS-CoV-2 pathobiology, the status of the vitamin D endocrine system and …