Case fatality rates for patients with COVID-19 requiring invasive mechanical ventilation. A meta-analysis
ZJ Lim, A Subramaniam, M Ponnapa Reddy… - American journal of …, 2021 - atsjournals.org
Rationale: Initial reports of case fatality rates (CFRs) among adults with coronavirus disease
(COVID-19) receiving invasive mechanical ventilation (IMV) are highly variable. Objectives …
(COVID-19) receiving invasive mechanical ventilation (IMV) are highly variable. Objectives …
[HTML][HTML] The immunology of SARS-CoV-2 infections and vaccines
L Grigoryan, B Pulendran - Seminars in immunology, 2020 - Elsevier
Abstract SARS-CoV-2, the virus that causes COVID-19, emerged in late 2019, and was
declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million …
declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million …
[HTML][HTML] Innate receptor activation patterns involving TLR and NLR synergisms in COVID-19, ALI/ARDS and sepsis cytokine storms: a review and model making novel …
R Root-Bernstein - International journal of molecular sciences, 2021 - mdpi.com
Severe COVID-19 is characterized by a “cytokine storm”, the mechanism of which is not yet
understood. I propose that cytokine storms result from synergistic interactions among Toll …
understood. I propose that cytokine storms result from synergistic interactions among Toll …
[HTML][HTML] Micronutrients, phytochemicals and mediterranean diet: A potential protective role against COVID-19 through modulation of PAF actions and metabolism
P Detopoulou, CA Demopoulos, S Antonopoulou - Nutrients, 2021 - mdpi.com
The new coronavirus disease 2019 (COVID-19) pandemic is an emerging situation with high
rates of morbidity and mortality, in the pathophysiology of which inflammation and …
rates of morbidity and mortality, in the pathophysiology of which inflammation and …
[HTML][HTML] Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions
IL Kruglikov, M Shah, PE Scherer - Elife, 2020 - elifesciences.org
Obesity and diabetes are established comorbidities for COVID-19. Adipose tissue
demonstrates high expression of ACE2 which SARS-CoV-2 exploits to enter host cells. This …
demonstrates high expression of ACE2 which SARS-CoV-2 exploits to enter host cells. This …
N-acetyl-cysteine reduces the risk for mechanical ventilation and mortality in patients with COVID-19 pneumonia: a two-center retrospective cohort study
SF Assimakopoulos, D Aretha, D Komninos… - Infectious …, 2021 - Taylor & Francis
Background N-acetyl-cysteine (NAC) has been previously shown to exert beneficial effects
in diverse respiratory diseases, through antioxidant and anti-inflammatory actions. Our aim …
in diverse respiratory diseases, through antioxidant and anti-inflammatory actions. Our aim …
[HTML][HTML] Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients
Mucosal barrier alterations may play a role in the pathogenesis of several diseases,
including COVID-19. In this study we evaluate the association between bacterial …
including COVID-19. In this study we evaluate the association between bacterial …
[HTML][HTML] The role of endotoxin in septic shock
Septic shock can be caused by a variety of mechanisms including direct effects of bacterial
toxins such as endotoxin. Annually, approximately 5–7 million patients worldwide develop …
toxins such as endotoxin. Annually, approximately 5–7 million patients worldwide develop …
[HTML][HTML] Persistent systemic microbial translocation and intestinal damage during coronavirus disease-19
A Oliva, MC Miele, F Di Timoteo, M De Angelis… - Frontiers in …, 2021 - frontiersin.org
Microbial translocation (MT) and intestinal damage (ID) are poorly explored in COVID-19.
Aims were to assess whether alteration of gut permeability and cell integrity characterize …
Aims were to assess whether alteration of gut permeability and cell integrity characterize …
[HTML][HTML] Gut barrier damage and gut translocation of pathogen molecules in lupus, an impact of innate immunity (macrophages and neutrophils) in autoimmune …
A Charoensappakit, K Sae-Khow… - International journal of …, 2022 - mdpi.com
The gut barrier is a single cell layer that separates gut micro-organisms from the host, and
gut permeability defects result in the translocation of microbial molecules from the gut into …
gut permeability defects result in the translocation of microbial molecules from the gut into …