Coumarin: A natural, privileged and versatile scaffold for bioactive compounds
A Stefanachi, F Leonetti, L Pisani, M Catto, A Carotti - Molecules, 2018 - mdpi.com
Many naturally occurring substances, traditionally used in popular medicines around the
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …
Synthesis and application of coumarin fluorescence probes
X Sun, T Liu, J Sun, X Wang - RSC advances, 2020 - pubs.rsc.org
In recent years, the research on fluorescent probes has developed rapidly. Coumarin
fluorescent probes have also been one of the hot topics in recent years. For the synthesis …
fluorescent probes have also been one of the hot topics in recent years. For the synthesis …
Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Design and synthesis of methoxyphenyl-and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of …
Exaggerated inflammatory responses may cause serious and debilitating diseases such as
acute lung injury and rheumatoid arthritis. Two series of chalcone derivatives were prepared …
acute lung injury and rheumatoid arthritis. Two series of chalcone derivatives were prepared …
[HTML][HTML] Anti-Alzheimer's disease potential of traditional chinese medicinal herbs as inhibitors of BACE1 and AChE enzymes
R Dai, Y Sun, R Su, H Gao - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Alzheimer's disease (AD) is a common neurodegenerative disease that often occurs in the
elderly population. At present, most drugs for AD on the market are single-target drugs …
elderly population. At present, most drugs for AD on the market are single-target drugs …
Synthetic and natural coumarins as potent anticonvulsant agents: A review with structure–activity relationship
RS Keri, S Budagumpi… - Journal of Clinical …, 2022 - Wiley Online Library
What is known and objective The main objective of this review is to highlight the most
relevant studies since 1990 (to date) in the area of medicinal chemistry aspects to provide a …
relevant studies since 1990 (to date) in the area of medicinal chemistry aspects to provide a …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids
Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …
Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways
Natural and synthetic coumarins have been extensively described in the literature as
effective drugs with several pharmacological activities. Many valuable publications have …
effective drugs with several pharmacological activities. Many valuable publications have …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies
Abstract Two new series of 1, 3, 4-oxadiazole and coumarin derivatives based on pyrimidine-
5-carbonitrile scaffold have been synthesized and evaluated for their COX-1/COX-2 …
5-carbonitrile scaffold have been synthesized and evaluated for their COX-1/COX-2 …