Many naturally occurring substances, traditionally used in popular medicines around the
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …

In recent years, the research on fluorescent probes has developed rapidly. Coumarin
fluorescent probes have also been one of the hot topics in recent years. For the synthesis …

Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …

Exaggerated inflammatory responses may cause serious and debilitating diseases such as
acute lung injury and rheumatoid arthritis. Two series of chalcone derivatives were prepared …

Alzheimer's disease (AD) is a common neurodegenerative disease that often occurs in the
elderly population. At present, most drugs for AD on the market are single-target drugs …

What is known and objective The main objective of this review is to highlight the most
relevant studies since 1990 (to date) in the area of medicinal chemistry aspects to provide a …

Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …

Natural and synthetic coumarins have been extensively described in the literature as
effective drugs with several pharmacological activities. Many valuable publications have …

Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …

Abstract Two new series of 1, 3, 4-oxadiazole and coumarin derivatives based on pyrimidine-
5-carbonitrile scaffold have been synthesized and evaluated for their COX-1/COX-2 …