Diabetes mellitus and the associated complications are metabolic diseases with high
morbidity that result in poor quality of health and life. The lack of diagnostic methods for early …

Glucose homeostasis is maintained by the glucoregulatory hormones, glucagon, insulin and
somatostatin, secreted from the islets of Langerhans. Glucagon is the body's most important …

Diabetes is a global public health burden and is characterized clinically by relative or
absolute insulin deficiency. Therapeutic agents that stimulate insulin secretion and improve …

Neutrophils have a pathogenic function in inflammation via releasing pro-inflammatory
mediators or neutrophil extracellular traps (NETs). However, their heterogeneity and pro …

Neuropeptide Y (NPY) exerts a powerful orexigenic effect in the hypothalamus. However,
extra-hypothalamic nuclei also produce NPY, but its influence on energy homeostasis is …

Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here
we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) …

Chronic stress fuels the consumption of palatable food and can enhance obesity
development. While stress-and feeding-controlling pathways have been identified, how …

A variety of studies indicate that microRNAs (miRNAs) are involved in diabetes. However,
the direct role of miR-320a in the pathophysiology of pancreatic β cells under diabetes …

Cocaine-and amphetamine-regulated transcript (CART) is widely expressed in the
hypothalamus and an important regulator of energy homeostasis; however, the specific …

Objectives Loss of functional β-cell mass is a key factor contributing to poor glycemic control
in advanced type 2 diabetes (T2D). We have previously reported that the inhibition of the …