Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Background: Alzheimer's disease (AD) as the most common cause of dementia among older
people has aroused the universal concern of the whole world. However, until now there is …

Aggregation of intrinsically disordered proteins (IDPs), such as amyloid beta peptide, can
cause serious health problems, associated with disorders including Alzheimer disease. Due …

Despite years of intensive research, little is known about oligomeric structures present
during Alzheimer's disease (AD). Excess of amyloid beta (Aβ) peptides and their …

Understanding the key factors that govern the rate of protein aggregation is of immense
interest since protein aggregation is associated with a number of neurodegenerative …

Protein aggregation has been studied by many groups around the world for many years
because it can be the cause of a number of neurodegenerative diseases that have no …

Although genome-wide association studies have identified multiple Alzheimer's disease
(AD)-associated loci by selecting the main effects of individual single-nucleotide …

Alzheimer's disease is presumed to be caused by the formation of intracellular plaques of
amyloid β (Aβ) peptides inside neurons. The most abundant Aβ forms are Aβ40 and Aβ42 …

In Alzheimer's disease (AD), amyloid β (Aβ) protein plays a detrimental role in neuronal
injury and death. Recent in vitro and in vivo studies suggest that soluble oligomers of the Aβ …

Amyloid imaging demonstrates the in vivo presence of amyloid-β (Aβ) deposits in the aging
human brain but it is still unknown which structural forms and modifications of Aβ are …