Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with reported
prevalence in the United States of 1 in 59 children (approximately 1.7%). Core deficits are …

Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the
hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light …

Background: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal
gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of …

Autism spectrum disorder (ASD) refers to complex neurobehavioral and
neurodevelopmental conditions characterized by impaired social interaction and …

The purposes of this paper are to provide an overview of the state of the science of sleep in
children with autism spectrum disorder (ASD), present hypotheses for the high prevalence of …

Background: A compelling number of studies, conducted in both children and adults, have
reported an association between sleep disturbances/circadian sleep alterations and autism …

Although there is evidence that significant sleep problems are common in children with
autism spectrum disorder (ASD) and that poor sleep exacerbates problematic daytime …

Several studies support currently the hypothesis that autism etiology is based on a polygenic
and epistatic model. However, despite advances in epidemiological, molecular and clinical …

Background/purpose Melatonin, an indoleamine secreted by the pineal gland, plays a key
role in regulating circadian rhythm. It has chronobiotic, antioxidant, anti-inflammatory and …