Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease
J Nowell, E Blunt, P Edison - Molecular Psychiatry, 2023 - nature.com
Despite an ever-growing prevalence and increasing economic burden of Alzheimer's
disease (AD) and Parkinson's disease (PD), recent advances in drug development have …
disease (AD) and Parkinson's disease (PD), recent advances in drug development have …
Type 3 diabetes and its role implications in Alzheimer's disease
TT Nguyen, QTH Ta, TKO Nguyen… - International journal of …, 2020 - mdpi.com
The exact connection between Alzheimer's disease (AD) and type 2 diabetes is still in
debate. However, poorly controlled blood sugar may increase the risk of developing …
debate. However, poorly controlled blood sugar may increase the risk of developing …
The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review
N Reich, C Hölscher - Frontiers in neuroscience, 2022 - frontiersin.org
Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …
[HTML][HTML] Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease
J Nowell, E Blunt, D Gupta, P Edison - Ageing Research Reviews, 2023 - Elsevier
Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …
Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions
Abstract Insulin-like growth factor-1 (IGF-1), a pleiotropic polypeptide, plays an essential role
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …
Brain insulin resistance: role in neurodegenerative disease and potential for targeting
C Hölscher - Expert opinion on investigational drugs, 2020 - Taylor & Francis
Introduction: This review evaluates the novel strategy of treating Alzheimer's and Parkinson's
disease (AD and PD) withdrugs that initially have been developed to treat type 2 diabetes …
disease (AD and PD) withdrugs that initially have been developed to treat type 2 diabetes …
Protective properties of GLP‐1 and associated peptide hormones in neurodegenerative disorders
C Hölscher - British journal of pharmacology, 2022 - Wiley Online Library
Type 2 diabetes mellitus and the associated desensitisation of insulin signalling has been
identified as a risk factor for progressive neurodegenerative disorders such as Alzheimer's …
identified as a risk factor for progressive neurodegenerative disorders such as Alzheimer's …
Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics
Among the more promising treatments proposed for Alzheimer's disease (AD) and
Parkinson's disease (PD) are those reducing brain insulin resistance. The antidiabetics in …
Parkinson's disease (PD) are those reducing brain insulin resistance. The antidiabetics in …
Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent
neurodegenerative disorders. Despite their pathophysiological and clinical differences, they …
neurodegenerative disorders. Despite their pathophysiological and clinical differences, they …
Cognitive dysfunction: a growing link between diabetes and Alzheimer's disease
K Jash, P Gondaliya, P Kirave… - Drug development …, 2020 - Wiley Online Library
Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting
millions of people worldwide. Diabetes is associated with various complications like …
millions of people worldwide. Diabetes is associated with various complications like …