Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease

J Nowell, E Blunt, P Edison - Molecular Psychiatry, 2023 - nature.com
Despite an ever-growing prevalence and increasing economic burden of Alzheimer's
disease (AD) and Parkinson's disease (PD), recent advances in drug development have …

Type 3 diabetes and its role implications in Alzheimer's disease

TT Nguyen, QTH Ta, TKO Nguyen… - International journal of …, 2020 - mdpi.com
The exact connection between Alzheimer's disease (AD) and type 2 diabetes is still in
debate. However, poorly controlled blood sugar may increase the risk of developing …

The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review

N Reich, C Hölscher - Frontiers in neuroscience, 2022 - frontiersin.org
Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

[HTML][HTML] Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease

J Nowell, E Blunt, D Gupta, P Edison - Ageing Research Reviews, 2023 - Elsevier
Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …

Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions

S Bhalla, S Mehan, A Khan, MU Rehman - Neuroscience & Biobehavioral …, 2022 - Elsevier
Abstract Insulin-like growth factor-1 (IGF-1), a pleiotropic polypeptide, plays an essential role
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …

Brain insulin resistance: role in neurodegenerative disease and potential for targeting

C Hölscher - Expert opinion on investigational drugs, 2020 - Taylor & Francis
Introduction: This review evaluates the novel strategy of treating Alzheimer's and Parkinson's
disease (AD and PD) withdrugs that initially have been developed to treat type 2 diabetes …

Protective properties of GLP‐1 and associated peptide hormones in neurodegenerative disorders

C Hölscher - British journal of pharmacology, 2022 - Wiley Online Library
Type 2 diabetes mellitus and the associated desensitisation of insulin signalling has been
identified as a risk factor for progressive neurodegenerative disorders such as Alzheimer's …

Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics

TS Salameh, EM Rhea, K Talbot, WA Banks - Biochemical pharmacology, 2020 - Elsevier
Among the more promising treatments proposed for Alzheimer's disease (AD) and
Parkinson's disease (PD) are those reducing brain insulin resistance. The antidiabetics in …

Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives

F Ferrari, A Moretti, RF Villa - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent
neurodegenerative disorders. Despite their pathophysiological and clinical differences, they …

Cognitive dysfunction: a growing link between diabetes and Alzheimer's disease

K Jash, P Gondaliya, P Kirave… - Drug development …, 2020 - Wiley Online Library
Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting
millions of people worldwide. Diabetes is associated with various complications like …