Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems

B Koskella, CA Hernandez… - Annual Review of …, 2022 - annualreviews.org
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …

Development of antibiofilm therapeutics strategies to overcome antimicrobial drug resistance

S Nadar, T Khan, SG Patching, A Omri - Microorganisms, 2022 - mdpi.com
A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix
produced by themselves. Many types of microorganisms that are found on living hosts or in …

Biological foundations of successful bacteriophage therapy

C Venturini, A Petrovic Fabijan… - EMBO Molecular …, 2022 - embopress.org
Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

Bacteriophages evolve enhanced persistence to a mucosal surface

WH Chin, C Kett, O Cooper… - Proceedings of the …, 2022 - National Acad Sciences
The majority of viruses within the gut are obligate bacterial viruses known as bacteriophages
(phages). Their bacteriotropism underscores the study of phage ecology in the gut, where …

Advances and challenges in cataloging the human gut virome

J Li, F Yang, M Xiao, A Li - Cell Host & Microbe, 2022 - cell.com
The human gut virome, which is often referred to as the" dark matter" of the gut microbiome,
remains understudied. A better understanding of the composition and variations of the gut …

Evaluation of computational phage detection tools for metagenomic datasets

KE Schackart III, JB Graham, AJ Ponsero… - Frontiers in …, 2023 - frontiersin.org
Introduction As new computational tools for detecting phage in metagenomes are being
rapidly developed, a critical need has emerged to develop systematic benchmarks. Methods …

Trans-kingdom interactions in mixed biofilm communities

FA Sadiq, MF Hansen, M Burmølle… - FEMS microbiology …, 2022 - academic.oup.com
The microbial world represents a phenomenal diversity of microorganisms from different
kingdoms of life, which occupy an impressive set of ecological niches. Most, if not all …

Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University

S Würstle, A Lee, KE Kortright, F Winzig, W An… - Scientific Reports, 2024 - nature.com
Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent
bacterial infections, and the year 2021 marked the centennial of Felix d'Hérelle's first …

Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells

MC Bond, L Vidakovic, PK Singh, K Drescher… - Elife, 2021 - elifesciences.org
Bacteriophages can be trapped in the matrix of bacterial biofilms, such that the cells inside
them are protected. It is not known whether these phages are still infectious and whether …

Experimental evolution at ecological scales allows linking of viral genotypes to specific host strains

MD Ramos-Barbero, B Aldeguer-Riquelme… - The ISME …, 2024 - academic.oup.com
Viruses shape microbial community structure and activity through the control of population
diversity and cell abundances. Identifying and monitoring the dynamics of specific virus-host …