Profiling metabolites and peptides in single cells
The intracellular levels and spatial localizations of metabolites and peptides reflect the state
of a cell and its relationship to its surrounding environment. Moreover, the amounts and …
of a cell and its relationship to its surrounding environment. Moreover, the amounts and …
Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact
KJ Boggio, E Obasuyi, K Sugino… - Expert review of …, 2011 - Taylor & Francis
Single-cell analysis is gaining popularity in the field of mass spectrometry as a method for
analyzing protein and peptide content in cells. The spatial resolution of MALDI mass …
analyzing protein and peptide content in cells. The spatial resolution of MALDI mass …
Peptidomics coming of age: a review of contributions from a bioinformatics angle
G Menschaert, TTM Vandekerckhove… - Journal of proteome …, 2010 - ACS Publications
The term peptidomics for a new promising “omics” field was not introduced until the
beginning of 2000. The approach has been proven successful in several domains such as …
beginning of 2000. The approach has been proven successful in several domains such as …
The spectral networks paradigm in high throughput mass spectrometry
A Guthals, JD Watrous, PC Dorrestein… - Molecular …, 2012 - pubs.rsc.org
High-throughput proteomics is made possible by a combination of modern mass
spectrometry instruments capable of generating many millions of tandem mass (MS2) …
spectrometry instruments capable of generating many millions of tandem mass (MS2) …
PACAP and other neuropeptide targets link chronic migraine and opioid-induced hyperalgesia in mouse models
Chronic use of opioids can produce opioid-induced hyperalgesia (OIH), and when used to
treat migraine, these drugs can result in increased pain and headache chronicity. We …
treat migraine, these drugs can result in increased pain and headache chronicity. We …
[HTML][HTML] G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei–serpentine gateways to neuroendocrine homeostasis
G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors in
the mammalian genome. They are activated by a multitude of different ligands that elicit …
the mammalian genome. They are activated by a multitude of different ligands that elicit …
Endogenous peptide discovery of the rat circadian clock: a focused study of the suprachiasmatic nucleus by ultrahigh performance tandem mass spectrometry
JE Lee, N Atkins, NG Hatcher, L Zamdborg… - Molecular & Cellular …, 2010 - ASBMB
Understanding how a small brain region, the suprachiasmatic nucleus (SCN), can
synchronize the body's circadian rhythms is an ongoing research area. This important time …
synchronize the body's circadian rhythms is an ongoing research area. This important time …
NeuroPedia: neuropeptide database and spectral library
Y Kim, S Bark, V Hook, N Bandeira - Bioinformatics, 2011 - academic.oup.com
Neuropeptides are essential for cell–cell communication in neurological and endocrine
physiological processes in health and disease. While many neuropeptides have been …
physiological processes in health and disease. While many neuropeptides have been …
Peptidomic analysis of human cell lines
Peptides have been proposed to function in intracellular signaling within the cytosol.
Although cytosolic peptides are considered to be highly unstable, a large number of …
Although cytosolic peptides are considered to be highly unstable, a large number of …
Selective separation and enrichment of peptides for MS analysis using the microspheres composed of Fe3O4@ nSiO2 core and perpendicularly aligned mesoporous …
In this work, we report the development of a novel enrichment protocol for peptides by using
the microspheres composed of Fe3O4@ nSiO2 Core and perpendicularly aligned …
the microspheres composed of Fe3O4@ nSiO2 Core and perpendicularly aligned …