Viral vector‐based gene therapies in the clinic
Gene therapies are currently one of the most investigated therapeutic modalities in both the
preclinical and clinical settings and have shown promise in treating a diverse spectrum of …
preclinical and clinical settings and have shown promise in treating a diverse spectrum of …
An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications
AT Russo, DW Grosenbach… - Expert review of anti …, 2021 - Taylor & Francis
ABSTRACT Introduction Tecovirimat (TPOXX®; ST-246) was approved for the treatment of
symptomatic smallpox by the USFDA in July of 2018 and has been stockpiled by the US …
symptomatic smallpox by the USFDA in July of 2018 and has been stockpiled by the US …
[HTML][HTML] Oncolytic viruses: newest frontier for cancer immunotherapy
MM Rahman, G McFadden - Cancers, 2021 - mdpi.com
Simple Summary Oncolytic viruses (OVs) are viruses that selectively target and kill cancer
cells while sparing normal ones. OVs are from diverse families of viruses, but naturally …
cells while sparing normal ones. OVs are from diverse families of viruses, but naturally …
[HTML][HTML] Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
JPW Heidbuechel, CE Engeland - Journal of hematology & oncology, 2021 - Springer
Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that
redirect T cells to tumor surface antigens. While efficacious against certain hematological …
redirect T cells to tumor surface antigens. While efficacious against certain hematological …
[HTML][HTML] Giving oncolytic viruses a free ride: carrier cells for oncolytic virotherapy
A Reale, A Calistri, J Altomonte - Pharmaceutics, 2021 - mdpi.com
Oncolytic viruses (OVs) are an emerging class of therapeutics which combine multiple
mechanisms of action, including direct cancer cell-killing, immunotherapy and gene therapy …
mechanisms of action, including direct cancer cell-killing, immunotherapy and gene therapy …
[HTML][HTML] Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor …
L Chen, H Chen, J Ye, Y Ge, H Wang, E Dai, J Ren… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Newly emerging cancer immunotherapy has led to significant progress in
cancer treatment; however, its efficacy is limited in solid tumors since the majority of them …
cancer treatment; however, its efficacy is limited in solid tumors since the majority of them …
[HTML][HTML] Ferroptosis inducer improves the efficacy of oncolytic virus-mediated cancer immunotherapy
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the
accumulation of lipid peroxides. In this study, we explore the combination of a ferroptosis …
accumulation of lipid peroxides. In this study, we explore the combination of a ferroptosis …
[HTML][HTML] Oncolytic adenovirus as pancreatic cancer-targeted therapy: Where do we go from here?
Pancreatic cancer remains one of the deadliest cancers with extremely high mortality rate,
and the number of cases is expected to steadily increase with time. Pancreatic cancer is …
and the number of cases is expected to steadily increase with time. Pancreatic cancer is …
[HTML][HTML] CD19-targeted BiTE expression by an oncolytic vaccinia virus significantly augments therapeutic efficacy against B-cell lymphoma
W Lei, Q Ye, Y Hao, J Chen, Y Huang, L Yang… - Blood cancer …, 2022 - nature.com
Immunotherapy with CD19-targeting bispecific T-cell engagers (CD19BiTEs) has
demonstrated highly effective killing of cancer cells in patients with precursor acute …
demonstrated highly effective killing of cancer cells in patients with precursor acute …
[HTML][HTML] Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for …
The approval of different cytokines as anti-neoplastic agents has been challenged by dose-
limiting toxicities. Although reducing dose levels affords improved tolerability, efficacy is …
limiting toxicities. Although reducing dose levels affords improved tolerability, efficacy is …