Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …

Living systems exhibit remarkable abilities to self-assemble, regenerate, and remodel
complex shapes. How cellular networks construct and repair specific anatomical outcomes …

High-throughput technologies for DNA sequencing and for analyses of transcriptomes,
proteomes and metabolomes have provided the foundations for deciphering the structure …

The aim of systems biology is to describe and understand biology at a global scale where
biological functions are recognised as a result of complex mechanisms that happen at …

Mathematical and computational models are increasingly used to help interpret biomedical
data produced by high-throughput genomics and proteomics projects. The application of …

Understanding how dynamic molecular networks affect whole-organism physiology,
analogous to mapping genotype to phenotype, remains a key challenge in biology …

A prerequisite for the systems biology analysis of tissues is an accurate digital three-
dimensional reconstruction of tissue structure based on images of markers covering multiple …

Computational models of cardiac electrophysiology are exemplar demonstrations of the
integration of multiple data sets into a consistent biophysical framework. These models …

Biomedical research frequently involves performing experiments and developing
hypotheses that link different scales of biological systems such as, for instance, the scales of …