[HTML][HTML] Mechanoresponsive metabolism in cancer cell migration and metastasis
Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …
not only proliferation but also migration. While migrating through a mechanically and …
Mechanical forces in tumor angiogenesis
MR Zanotelli, CA Reinhart-King - Biomechanics in Oncology, 2018 - Springer
A defining hallmark of cancer and cancer development is upregulated angiogenesis. The
vasculature formed in tumors is structurally abnormal, not organized in the conventional …
vasculature formed in tumors is structurally abnormal, not organized in the conventional …
Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
MR Zanotelli, A Rahman-Zaman… - Nature …, 2019 - nature.com
Cell migration during the invasion-metastasis cascade requires cancer cells to navigate a
spatially complex microenvironment that presents directional choices to migrating cells …
spatially complex microenvironment that presents directional choices to migrating cells …
Cell cytoskeleton and stiffness are mechanical indicators of organotropism in breast cancer
Simple Summary Cancer cell dissemination exhibits organ preference or organotropism.
Although the influence of intrinsic biochemical factors on organotropism has been intensely …
Although the influence of intrinsic biochemical factors on organotropism has been intensely …
[HTML][HTML] Tension directs cancer cell migration over fiber alignment through energy minimization
Cell migration during many fundamental biological processes including metastasis requires
cells to traverse tissue with heterogeneous mechanical cues that direct migration as well as …
cells to traverse tissue with heterogeneous mechanical cues that direct migration as well as …
Acousto-holographic reconstruction of whole-cell stiffness maps
Accurate assessment of cell stiffness distribution is essential due to the critical role of cell
mechanobiology in regulation of vital cellular processes like proliferation, adhesion …
mechanobiology in regulation of vital cellular processes like proliferation, adhesion …
Gold nano-bio-interaction to modulate mechanobiological responses for cancer therapy applications
A Sohrabi Kashani, K Larocque, A Piekny… - ACS Applied Bio …, 2022 - ACS Publications
In the present study, we investigate the mechanobiological responses of human lung cancer
that may occur through their interactions with two different types of gold nanoparticles …
that may occur through their interactions with two different types of gold nanoparticles …
Quantitative assessment of cell contractility using polarized light microscopy
Cell contractility regulates multiple cell behaviors which contribute to both normal and
pathological processes. However, measuring cell contractility remains a technical challenge …
pathological processes. However, measuring cell contractility remains a technical challenge …
[HTML][HTML] Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death
C Dziengelewski, MA Rodrigue, A Caillier… - Journal of Cell …, 2020 - rupress.org
The tumor cell–selective killing activity of the adenovirus type 2 early region 4 ORF4 (E4orf4)
protein is poorly defined at the molecular level. Here, we show that the tumoricidal effect of …
protein is poorly defined at the molecular level. Here, we show that the tumoricidal effect of …
Nanoscale characterization of dynamic cellular viscoelasticity by atomic force microscopy with varying measurement parameters
Cell mechanics plays an important role in regulating the physiological activities of cells. The
advent of atomic force microscopy (AFM) provides a novel powerful instrument for …
advent of atomic force microscopy (AFM) provides a novel powerful instrument for …