Normal cell-cycle progression is a crucial task for every multicellular organism, as it
determines body size and shape, tissue renewal and senescence, and is also crucial for …

Mitochondria are biosynthetic, bioenergetic, and signaling organelles which are critical for
physiological adaptations and cellular stress responses to the environment. Various …

All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …

Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an
intracellular signaling species. The phospholipase D superfamily plays a central role in a …

Tension applied to the plasma membrane (PM) is a global mechanical parameter involved
in cell migration. However, how membrane tension regulates actin assembly is unknown …

Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates
phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular …

Clinically important links have been established between mitochondrial function and cardiac
physiology and disease in the context of signaling mechanisms, energy production, and …

Dendritic spines are small, bulbous protrusions along neuronal dendrites where most of the
excitatory synapses are located. Dendritic spine density in normal human brain increases …

Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to generate phosphatidic
acid (PA). Mammalian DGK consists of ten isozymes (α–κ) and governs a wide range of …

Breast cancer is one of the most common malignancies in human females in the world. One
protein that has elevated enzymatic lipase activity in breast cancers in vitro is phospholipase …