Physiology of the cerebellum

E D'Angelo - Handbook of clinical neurology, 2018 - Elsevier
The cerebellum is a central brain structure deeply integrated into major loops with the
cerebral cortex, brainstem, and spinal cord. The cerebellum shows a complex regional …

Human-scale brain simulation via supercomputer: a case study on the cerebellum

T Yamazaki, J Igarashi, H Yamaura - Neuroscience, 2021 - Elsevier
Performance of supercomputers has been steadily and exponentially increasing for the past
20 years, and is expected to increase further. This unprecedented computational power …

[HTML][HTML] Reconstruction and simulation of a scaffold model of the cerebellar network

S Casali, E Marenzi, C Medini, C Casellato… - Frontiers in …, 2019 - frontiersin.org
Reconstructing neuronal microcircuits through computational models is fundamental to
simulate local neuronal dynamics. Here a scaffold model of the cerebellum has been …

A cerebellum-inspired prediction and correction model for motion control of a musculoskeletal robot

J Zhang, J Chen, W Wu, H Qiao - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
It is an important issue that how to regulate the existing control models of musculoskeletal
robots to improve the ability of motion learning and generalization. In this article, based on …

Simulation of a human-scale cerebellar network model on the K computer

H Yamaura, J Igarashi, T Yamazaki - Frontiers in neuroinformatics, 2020 - frontiersin.org
Computer simulation of the human brain at an individual neuron resolution is an ultimate
goal of computational neuroscience. The Japanese flagship supercomputer, K, provides …

Hyperexcitable neurons enable precise and persistent information encoding in the superficial retrosplenial cortex

EKW Brennan, SK Sudhakar, I Jedrasiak-Cape… - Cell reports, 2020 - cell.com
The retrosplenial cortex (RSC) is essential for memory and navigation, but the neural codes
underlying these functions remain largely unknown. Here, we show that the most prominent …

Cellular-resolution mapping uncovers spatial adaptive filtering at the rat cerebellum input stage

S Casali, M Tognolina, D Gandolfi, J Mapelli… - Communications …, 2020 - nature.com
Long-term synaptic plasticity is thought to provide the substrate for adaptive computation in
brain circuits but very little is known about its spatiotemporal organization. Here, we …

Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity

S Masoli, A Ottaviani, S Casali… - PLOS Computational …, 2020 - journals.plos.org
The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer.
Although recent works have highlighted the complexity of their dendritic organization and …

Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity

I Straub, L Witter, A Eshra, M Hoidis, N Byczkowicz… - Elife, 2020 - elifesciences.org
Cerebellar granule cells (GCs) make up the majority of all neurons in the vertebrate brain,
but heterogeneities among GCs and potential functional consequences are poorly …

Hyperexcitability and hyperplasticity disrupt cerebellar signal transfer in the IB2 KO mouse model of autism

T Soda, L Mapelli, F Locatelli, L Botta… - Journal of …, 2019 - Soc Neuroscience
Autism spectrum disorders (ASDs) are pervasive neurodevelopmental conditions that often
involve mutations affecting synaptic mechanisms. Recently, the involvement of cerebellum in …