Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …

In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly and
represents an important and increasing clinical challenge in terms of diagnosis and …

The clinical approach to patients with amyotrophic lateral sclerosis (ALS) has been largely
modified by the identification of novel genes, the detection of gene mutations in apparently …

Abstract Background Current Alzheimer's disease (AD) research initiatives focus on
cognitively healthy individuals with biomarkers that are associated with the development of …

Genetic testing is increasingly available in medical settings and direct-to-consumer.
However, the large and growing literature on genetic testing decisions is rife with conflicting …

Direct-to-consumer (DTC) genetic services have generated enormous controversy from their
first emergence. A dramatic recent manifestation of this is the Food and Drug …

Objective: Prevention trials for neurodegenerative diseases use genetic or other risk marker
tests to select participants but there is concern that this could involve coercive disclosure of …

Developments in genomics continue to increase the number of disorders for which genetic
testing is available, whether in the primary healthcare system, through direct-to-consumer …

Attitudes, Motivations, and Barriers to Pre-Symptomatic Alzheimer’s Disease Screening:
Development and Validation of the ‘Perceptions regarding pRE-symptomatic Alzheimer’s …