Pyruvate kinase is a key regulator in glycolysis through the conversion of
phosphoenolpyruvate (PEP) into pyruvate. Pyruvate kinase exists in various isoforms that …

Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-
dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the …

Ovarian cancer is the seventh most common cancer worldwide in women. Many anticancer
drugs are currently used clinically have been isolated from plant species or are based on …

Redox‐active substances and their combinations, such as of quinone/ascorbate and in
particular menadione/ascorbate (M/A; also named Apatone®), attract attention with their …

Naphthoquinones are important natural or synthetic compounds belonging to the general
class of quinones. Many compounds in this class have become drugs that are on the …

Vitamin K is an essential nutrient in the body and involved in numerous physiological and
pathophysiological functions. Both the lack and surplus of vitamin K can put human health at …

Background Secondary therapy-related acute lymphoblastic leukemia might emerge
following chemotherapy and/or radiotherapy for primary malignancies. Therefore, other …

Pyruvate kinase M2 (PKM2) is a rate-limiting enzyme of aerobic glycolysis in cancer cells
and plays important roles in cancer metabolism and growth. Here we show that vitamin K3 …

A human bladder carcinoma cell line RT4 was sham-treated with buffer or treated with
ascorbate (VC) alone, menadione alone (VK3), or a combination of ascorbate: menadione …

The expression of HNF1 homeobox B (HNF1B) is associated with cancer risk in several
tumors, including ovarian cancer, and its decreased expression play roles in cancer …