Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential
cation channel, subfamily C, member 6) were linked to development of familial forms of …

Diseases that induce a loss of renal function affect a substantial portion of the world's
population and can range from a slight decline in the glomerular filtration rate or …

Transient receptor potential canonical (TRPC) channels belong to an important class of non-
selective cation channels. This channel family consists of multiple members that widely …

Abstract Purpose of Review The underlining goal of this review is to offer a concise, detailed
look into current knowledge surrounding transient receptor potential canonical channel 6 …

Transient receptor potential canonical (TRPC) proteins assemble to form homo-or
heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC …

Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such
as diabetic kidney disease (DKD). Actin cytoskeleton rearrangement in podocyte induced by …

Background: Nephrotic syndrome (NS) is a common glomerular disease, and podocyte
injury is the character of primary NS, usually caused by minimal change disease and …

Renal fibrosis is the final common pathological manifestation of almost all progressive
chronic kidney diseases (CKD). Transient receptor potential canonical (TRPC) channels …