The emergence of drug resistance is a major challenge for oncologists. Resistance can be
categorized as acquired or intrinsic; the alteration of several biological mechanisms …

Progress in ovarian cancer treatment lags behind other tumor types. With diagnosis usually
at an advanced stage, there is a high demand for reliable prognostic biomarkers capable of …

DNA methylation has a substantial impact on gene expression, affecting the prognosis of
breast cancer (BC) patients dependent on molecular subtypes. In this study, we investigated …

Introduction Extensive research is directed to uncover new biomarkers capable to stratify
breast cancer patients into clinically relevant cohorts. However, the overall performance …

Genes showing higher expression in either tumor or metastatic tissues can help in better
understanding tumor formation and can serve as biomarkers of progression or as potential …

Systemic therapy of breast cancer can include chemotherapy, hormonal therapy and
targeted therapy. Prognostic biomarkers are able to predict survival and predictive …

Two large-scale pharmacogenomic studies were published recently in this journal. Genomic
data are well correlated between studies; however, the measured drug response data are …

Breast cancer stem cells (CSCs) are thought to drive recurrence and metastasis. Their
identity has been linked to the epithelial to mesenchymal transition (EMT) but remains highly …

Abstract Background and Purpose Survival rate of patients with lung cancer has increased
by over 60% in the recent two decades. With longer survival, the identification of genes …

DNA repair competency is one determinant of sensitivity to certain chemotherapy drugs,
such as cisplatin. Cancer cells with intact DNA repair can avoid the accumulation of genome …