Exposure protocol for ecotoxicity testing of microplastics and nanoplastics

F Abdolahpur Monikh, A Baun, NB Hartmann… - Nature …, 2023 - nature.com
Despite the increasing concern about the harmful effects of micro-and nanoplastics (MNPs),
there are no harmonized guidelines or protocols yet available for MNP ecotoxicity testing …

Hormesis: Highly generalizable and beyond laboratory

E Agathokleous, M Kitao, EJ Calabrese - Trends in Plant Science, 2020 - cell.com
Hormesis is a biphasic dose–response relationship with contrasting effects of low versus
high doses of stress. Hormesis is rapidly developing in plant science research and has wide …

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

BE Jones, PL Brown-Augsburger, KS Corbett… - Science translational …, 2021 - science.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health
threat for which preventive and therapeutic agents are urgently needed. Neutralizing …

Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology

L Ewart, A Apostolou, SA Briggs, CV Carman… - Communications …, 2022 - nature.com
Background Conventional preclinical models often miss drug toxicities, meaning the harm
these drugs pose to humans is only realized in clinical trials or when they make it to market …

Network medicine framework for identifying drug-repurposing opportunities for COVID-19

D Morselli Gysi, Í Do Valle, M Zitnik… - Proceedings of the …, 2021 - National Acad Sciences
The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …

Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy

A Alvarez-Varela, L Novellasdemunt, FM Barriga… - Nature Cancer, 2022 - nature.com
Colorectal cancer (CRC) patient-derived organoids predict responses to chemotherapy.
Here we used them to investigate relapse after treatment. Patient-derived organoids expand …

[HTML][HTML] Chemical composition and ecotoxicity of plastic and car tire rubber leachates to aquatic organisms

M Capolupo, L Sørensen, KDR Jayasena, AM Booth… - Water research, 2020 - Elsevier
Synthetic polymer-based materials are ubiquitous in aquatic environments, where
weathering processes lead to their progressive fragmentation and the leaching of additive …

[HTML][HTML] Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

SX Lu, E De Neef, JD Thomas, E Sabio, B Rousseau… - Cell, 2021 - cell.com
Although mutations in DNA are the best-studied source of neoantigens that determine
response to immune checkpoint blockade, alterations in RNA splicing within cancer cells …

Reporting the limits of detection and quantification for environmental DNA assays

KE Klymus, CM Merkes, MJ Allison… - Environmental …, 2020 - Wiley Online Library
Abstract Background Environmental DNA (eDNA) analysis is increasingly being used to
detect the presence and relative abundance of rare species, especially invasive or imperiled …

SARS-CoV-2 coronavirus nucleocapsid antigen-detecting half-strip lateral flow assay toward the development of point of care tests using commercially available …

BD Grant, CE Anderson, JR Williford… - Analytical …, 2020 - ACS Publications
The SARS-CoV-2 pandemic has created an unprecedented need for rapid diagnostic testing
to enable the efficient treatment and mitigation of COVID-19. The primary diagnostic tool …