DNA has played an early and powerful role in the development of bottom-up
nanotechnologies, not least because of DNA's precise, predictable, and controllable …

Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …

Abstract CRISPR-Cas12a (Cpf1) trans-cleaves ssDNA and this feature has been widely
harnessed for nucleic acid detection. Herein, we introduce a new type of Cas12a reporter, G …

G-quadruplexes adopt various folding topologies, but information on their folding pathways
remains scarce. Here, we used electrospray mass spectrometry to detect and quantify the …

First studies on thrombin-inhibiting DNA aptamers were reported in 1992, and since then a
large number of anticoagulant aptamers has been discovered. TBA–also named HD1, a 15 …

miRNA plays a vital role in many biological processes by regulating the expression of target
genes and is considered to be a promising disease biomarker. Although surface-enhanced …

Abstract G-Quadruplexes (G4s) are widely studied secondary DNA/RNA structures, naturally
occurring when G-rich sequences are present. The strategic localization of G4s in genome …