Major depressive disorder (MDD) is underlined by neurochemical changes in the brain.
Proton magnetic resonance spectroscopy (1 H MRS) is a useful tool for their examination as …

Chronic stress is depressogenic by altering neurotrophic and neuroinflammatory
environments of the organism. The endocannabinoid system controls cognitive and …

The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been
implicated in a wide range of behaviors and emotional states. Emerging evidence, primarily …

Curcumin is a major diarylheptanoid component of Curcuma longa with traditional usage for
anxiety and depression. It has been known for the anti‐inflammatory, antistress, and …

Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted
patients. Despite advances in the understanding of MDD and its treatment, profound …

Depression is a psychiatric disorder characterized by a marked decrease in reward
sensitivity. By using the olfactory bulbectomy (OBX) model of depression, it was shown that …

Objectives: Patients with schizophrenia often suffer comorbid substance abuse regardless of
gender. However, the vast majority of studies are only conducted in male subjects …

Cannabis sativa is one of the most widely recreational drugs and its use is more prevalent
among depressed patients. Some studies reported that Cannabis has antidepressant effects …

Olfactory bulbectomized (OBX) mice exhibit depressive-like behaviors and memory deficits.
We have reported that aripiprazole (ARI) ameliorates the behavioral hyper-responsivity to …

The opioid-induced rise of extracellular dopamine, endocannabinoid anandamide and γ-
aminobutyric acid (GABA) concentrations triggered by opioids in the nucleus accumbens …