The hippocampus is regarded as the pivotal structure for episodic memory symptoms
associated with Alzheimer's disease (AD) pathophysiology. However, what is often …

The thalamus is a central integration structure in the brain, receiving and distributing
information among the cerebral cortex, subcortical structures, and the peripheral nervous …

Alzheimer's disease (AD) is the most common cause of dementia worldwide. Increasing
evidence points to the thalamus as an important hub in the clinical symptomatology of the …

Abstracts Blood-brain barrier (BBB) impairment is an important pathophysiological process
in Alzheimer's disease (AD) and a potential biomarker for early diagnosis of AD. However …

Spatially resolved scRNA-seq (sp-scRNA-seq) technologies provide the potential to
comprehensively profile gene expression patterns in tissue context. However, the …

Alzheimer's disease (AD) and aging are intrinsically interconnected with each other and are
mediated by molecular, cellular, and biological systems. In particular, a specific pattern of …

Abstract Background Patients with Alzheimer's Disease (AD) exhibit structural alterations of
the thalamus that correlate with clinical symptoms. However, given the anatomical …

We aimed to study atrophy and glucose metabolism of the cholinergic basal forebrain in non-
demented mutation carriers for autosomal dominant Alzheimer's disease (ADAD). We …

Black-box deep learning (DL) models trained for the early detection of Alzheimer's Disease
(AD) often lack systematic model interpretation. This work computes the activated brain …

It has been proposed recently that major depressive disorder (MDD) could represent an
adaptation to conserve energy after the perceived loss of an investment in a vital source …