Mycobacterium tuberculosis and interactions with the host immune system: opportunities for nanoparticle based immunotherapeutics and vaccines
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a deadly infectious
disease. The thin pipeline of new drugs for TB, the ineffectiveness in adults of the only …
disease. The thin pipeline of new drugs for TB, the ineffectiveness in adults of the only …
Pyridine and quinoline molecules as crucial protagonists in the never-stopping discovery of new agents against tuberculosis
AF Villamizar-Mogotocoro, LY Vargas-Méndez… - European Journal of …, 2020 - Elsevier
Tuberculosis (TB) disease remains to be an alarming infection worldwide with nearly 1.6
million deaths per year ranking above HIV/AIDS. Although Mycobacterium tuberculosis …
million deaths per year ranking above HIV/AIDS. Although Mycobacterium tuberculosis …
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease
K Famulla, P Sass, I Malik, T Akopian… - Molecular …, 2016 - Wiley Online Library
The Clp protease complex in Mycobacterium tuberculosis is unusual in its composition,
functional importance and activation mechanism. Whilst most bacterial species contain a …
functional importance and activation mechanism. Whilst most bacterial species contain a …
Permeability of TB drugs through the mycolic acid monolayer: a tale of two force fields
Tuberculosis (TB) treatment becomes challenging due to the unique cell wall structure of
Mycobacterium tuberculosis (M. tb). Among various components of the M. tb cell wall …
Mycobacterium tuberculosis (M. tb). Among various components of the M. tb cell wall …
Mycobacterium tuberculosis Cell Wall Permeability Model Generation Using Chemoinformatics and Machine Learning Approaches
S Nagamani, GN Sastry - ACS omega, 2021 - ACS Publications
The drug-resistant strains of Mycobacterium tuberculosis (M. tb) are evolving at an alarming
rate, and this indicates the urgent need for the development of novel antitubercular drugs …
rate, and this indicates the urgent need for the development of novel antitubercular drugs …
Virtual Screening, pharmacophore development and structure based similarity search to identify inhibitors against IdeR, a transcription factor of Mycobacterium …
Abstract ideR, an essential gene of Mycobacterium tuberculosis, is an attractive drug target
as its conditional knockout displayed attenuated growth phenotype in vitro and in vivo. To …
as its conditional knockout displayed attenuated growth phenotype in vitro and in vivo. To …
Combining Computational Methods for Hit to Lead Optimization in Mycobacterium Tuberculosis Drug Discovery
S Ekins, JS Freundlich, JV Hobrath… - Pharmaceutical …, 2014 - Springer
Purpose Tuberculosis treatments need to be shorter and overcome drug resistance. Our
previous large scale phenotypic high-throughput screening against Mycobacterium …
previous large scale phenotypic high-throughput screening against Mycobacterium …
Free Energy Barriers for Passive Drug Transport through the Mycobacterium tuberculosis Outer Membrane: A Molecular Dynamics Study
IS Steshin, AV Vasyankin, EA Shirokova… - International Journal of …, 2024 - mdpi.com
The emergence of multi-drug-resistant tuberculosis strains poses a significant challenge to
modern medicine. The development of new antituberculosis drugs is hindered by the low …
modern medicine. The development of new antituberculosis drugs is hindered by the low …
Current advances in antitubercular drug discovery: Potent prototypes and new targets
G Felipe dos Santos Fernandes… - Current medicinal …, 2015 - ingentaconnect.com
Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium
genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to …
genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to …
[HTML][HTML] Structure-based in silico approaches for drug discovery against Mycobacterium tuberculosis
ADH Kingdon, LJ Alderwick - Computational and Structural Biotechnology …, 2021 - Elsevier
Mycobacterium tuberculosis is the causative agent of TB and was estimated to cause 1.4
million death in 2019, alongside 10 million new infections. Drug resistance is a growing …
million death in 2019, alongside 10 million new infections. Drug resistance is a growing …