Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a deadly infectious
disease. The thin pipeline of new drugs for TB, the ineffectiveness in adults of the only …

Tuberculosis (TB) disease remains to be an alarming infection worldwide with nearly 1.6
million deaths per year ranking above HIV/AIDS. Although Mycobacterium tuberculosis …

The Clp protease complex in Mycobacterium tuberculosis is unusual in its composition,
functional importance and activation mechanism. Whilst most bacterial species contain a …

Tuberculosis (TB) treatment becomes challenging due to the unique cell wall structure of
Mycobacterium tuberculosis (M. tb). Among various components of the M. tb cell wall …

The drug-resistant strains of Mycobacterium tuberculosis (M. tb) are evolving at an alarming
rate, and this indicates the urgent need for the development of novel antitubercular drugs …

Abstract ideR, an essential gene of Mycobacterium tuberculosis, is an attractive drug target
as its conditional knockout displayed attenuated growth phenotype in vitro and in vivo. To …

Purpose Tuberculosis treatments need to be shorter and overcome drug resistance. Our
previous large scale phenotypic high-throughput screening against Mycobacterium …

The emergence of multi-drug-resistant tuberculosis strains poses a significant challenge to
modern medicine. The development of new antituberculosis drugs is hindered by the low …

Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium
genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to …

Mycobacterium tuberculosis is the causative agent of TB and was estimated to cause 1.4
million death in 2019, alongside 10 million new infections. Drug resistance is a growing …