RNA-binding proteins and cancer metastasis
S Wang, Z Sun, Z Lei, HT Zhang - Seminars in cancer biology, 2022 - Elsevier
RNA-binding proteins (RBPs) can regulate gene expression through post-transcriptionally
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …
RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer
ABSTRACT RNA-binding proteins (RBPs) are key players in cellular physiology through
posttranscriptional regulation of the expression of target RNA transcripts. By modulating the …
posttranscriptional regulation of the expression of target RNA transcripts. By modulating the …
[HTML][HTML] AU-rich element RNA binding proteins: at the crossroads of post-transcriptional regulation and genome integrity
A Sidali, V Teotia, NS Solaiman, N Bashir… - International Journal of …, 2021 - mdpi.com
Genome integrity must be tightly preserved to ensure cellular survival and to deter the
genesis of disease. Endogenous and exogenous stressors that impose threats to genomic …
genesis of disease. Endogenous and exogenous stressors that impose threats to genomic …
Primary cilia control translation and the cell cycle in medulloblastoma
YH Youn, S Hou, CC Wu, D Kawauchi… - Genes & …, 2022 - genesdev.cshlp.org
The primary cilium, a signaling organelle projecting from the surface of a cell, controls
cellular physiology and behavior. The presence or absence of primary cilia is a distinctive …
cellular physiology and behavior. The presence or absence of primary cilia is a distinctive …
Targeting the RNA-binding protein HuR in cancer
The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models
G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously
expressed in human tissues, that orchestrates target RNA maturation and processing both in …
expressed in human tissues, that orchestrates target RNA maturation and processing both in …
[HTML][HTML] Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein
M Zhang, Y Xu, Y Zhang, B Li, G Lou - Cellular Signalling, 2021 - Elsevier
Ovarian cancer (OC) is a gynecological malignancy with a poor prognosis and low survival
rate. E2F2 is a transcription activator that plays an indispensable role in cell proliferation and …
rate. E2F2 is a transcription activator that plays an indispensable role in cell proliferation and …
Models and methods to study Schwann cells
S Negro, M Pirazzini, M Rigoni - Journal of Anatomy, 2022 - Wiley Online Library
Schwann cells (SCs) are fundamental components of the peripheral nervous system (PNS)
of all vertebrates and play essential roles in development, maintenance, function, and …
of all vertebrates and play essential roles in development, maintenance, function, and …
[HTML][HTML] Drug delivery approaches for HuR-targeted therapy for lung cancer
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for
disease management have limitations associated with them. Novel therapeutic targets are …
disease management have limitations associated with them. Novel therapeutic targets are …
[HTML][HTML] Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop
M Ma, J Zhuang, H Li, R Mi, Y Song, W Yang, Y Lu… - Oncogene, 2024 - nature.com
ZFP36L1, which is a negative regulator of gene transcripts, has been proven to regulate the
progression of several carcinomas. However, its role in sarcoma remains unknown. Here, by …
progression of several carcinomas. However, its role in sarcoma remains unknown. Here, by …