Cancer stem cells: advances in knowledge and implications for cancer therapy
X Chu, W Tian, J Ning, G Xiao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …
Stem cell fate in cancer growth, progression and therapy resistance
Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …
growth, and how these signals can be targeted, effective control of this disease remains a …
[HTML][HTML] Glioma stem cells and their roles within the hypoxic tumor microenvironment
Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …
unrestricted growth and proliferation and result in further modifications in cell behavior …
Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma
Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing
glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified …
glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified …
Radioresistance in Glioblastoma and the Development of Radiosensitizers
Simple Summary Numerous mechanisms of glioblastoma (GBM) radioresistance have been
identified but have not yet resulted in development of effective radiosensitizer that can …
identified but have not yet resulted in development of effective radiosensitizer that can …
Circadian regulator CLOCK recruits immune-suppressive microglia into the GBM tumor microenvironment
Glioblastoma (GBM) is a lethal brain tumor containing a subpopulation of glioma stem cells
(GSC). Pan-cancer analyses have revealed that stemness of cancer cells correlates …
(GSC). Pan-cancer analyses have revealed that stemness of cancer cells correlates …
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
V Giuliani, MA Miller, CY Liu, SR Hartono… - Nature …, 2021 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that has remained
clinically challenging to manage. Here we employ an RNAi-based in vivo functional …
clinically challenging to manage. Here we employ an RNAi-based in vivo functional …
[HTML][HTML] Targeting cancer stem cells and their niche: perspectives for future therapeutic targets and strategies
Y Zhao, Q Dong, J Li, K Zhang, J Qin, J Zhao… - Seminars in cancer …, 2018 - Elsevier
A small subpopulation of cells within the bulk of tumors share features with somatic stem
cells, in that, they are capable of self-renewal, they differentiate, and are highly resistant to …
cells, in that, they are capable of self-renewal, they differentiate, and are highly resistant to …
CD13 promotes hepatocellular carcinogenesis and sorafenib resistance by activating HDAC5‐LSD1‐NF‐κB oncogenic signaling
B Hu, Y Xu, YC Li, JF Huang, JW Cheng… - Clinical and …, 2020 - Wiley Online Library
Rationale CD13 is a new marker for liver cancer stem cells (CSCs) that contributes to
sorafenib resistance in hepatocellular carcinoma (HCC). However, the underlying …
sorafenib resistance in hepatocellular carcinoma (HCC). However, the underlying …
PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis
The DREAM complex orchestrates cell quiescence and the cell cycle. However, how the
DREAM complex is deregulated in cancer remains elusive. Here, we report that PAF …
DREAM complex is deregulated in cancer remains elusive. Here, we report that PAF …