Benzimidazole: a medicinally important heterocyclic moiety

B Narasimhan, D Sharma, P Kumar - Medicinal Chemistry Research, 2012 - Springer
Benzimidazole nucleus is a constituent of many bioactive heterocyclic compounds that are
of wide interest because of their diverse biological and clinical applications. Moreover …

[PDF][PDF] Benzimidazole derivatives–an overview

R Walia, M Hedaitullah, SF Naaz… - Int. J. Res. Pharm …, 2011 - cmapspublic3.ihmc.us
Benzimidazole derivatives play important role in medical field with so many
Pharmacological activities such as antimicrobial, antiviral, antidiabetic and anticancer …

Synthesis of 1, 2-disubstituted benzimidazoles, 2-substituted benzimidazoles and 2-substituted benzothiazoles in SDS micelles

K Bahrami, MM Khodaei, A Nejati - Green Chemistry, 2010 - pubs.rsc.org
A practical and convenient synthetic method has been developed for the facile synthesis of
1, 2-disubstituted benzimidazoles, 2-substituted benzimidazoles and 2-substituted …

Benzimidazoles in drug discovery: a patent review

CSW Law, KY Yeong - ChemMedChem, 2021 - Wiley Online Library
Benzimidazole is a heterocyclic ring system that has been widely studied in the
pharmaceutical field. For the past decade, numerous benzimidazole derivatives have been …

Benzimidazole: A promising pharmacophore

K Shah, S Chhabra, SK Shrivastava… - Medicinal Chemistry …, 2013 - Springer
The aim of this review is to provide an overview on diverse pharmacological activities of the
benzimidazole moiety. This review highlights recent reports of antimicrobial, anticancer …

Water mediated chemoselective synthesis of 1, 2-disubstituted benzimidazoles using o-phenylenediamine and the extended synthesis of quinoxalines

JP Wan, SF Gan, JM Wu, Y Pan - Green Chemistry, 2009 - pubs.rsc.org
By applying water as the reaction medium, the one-pot synthesis of 1, 2-disubstituted
benzimidazoles has been achieved in excellent efficiency and selectivity at room …

Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists—A perspective

P Naik, P Murumkar, R Giridhar, MR Yadav - Bioorganic & medicinal …, 2010 - Elsevier
Hypertension is a major risk factor for human morbidity and mortality through its effects on
target organs like heart, brain and kidneys. More intensive treatment for the effective control …

Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

OO Ajani, DV Aderohunmu, CO Ikpo… - Archiv der …, 2016 - Wiley Online Library
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …

[HTML][HTML] A critical review of benzimidazole: Sky-high objectives towards the lead molecule to predict the future in medicinal chemistry

S Banerjee, S Mukherjee, P Nath, A Mukherjee… - Results in …, 2023 - Elsevier
Out of several heterocyclic templates, the use of a Benzimidazole (BZ) scaffold is immensely
observed. This fused heterocycle comprises two ring nitrogen atoms placed at 1st and 3rd …

Magnetically separable MnFe 2 O 4 nano-material: an efficient and reusable heterogeneous catalyst for the synthesis of 2-substituted benzimidazoles and the …

G Brahmachari, S Laskar, P Barik - RSC advances, 2013 - pubs.rsc.org
A simple and efficient protocol has been developed for the synthesis of biologically relevant
2-substituted benzimidazoles and quinoxalines using magnetically separable manganese …