Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

Major depressive disorder (MDD) is a common psychiatric disorder with multifactorial
aetiology and complex pathophysiology. Despite availability of various pharmacological and …

Ketamine, a dissociative anesthetic and psychedelic compound, has revolutionized the field
of psychopharmacology by showing robust, and rapid-acting antidepressant activity in …

Nowadays depression is considered as a systemic illness with different biological
mechanisms involved in its etiology, including inflammatory response, hypothalamic …

Depression is a complex and highly heterogeneous disorder which diagnosis is based on
an exceedingly variable set of clinical symptoms. Current treatments focus almost …

Abstract Purpose of Review The following review will explore ketamine's antidepressant and
antisuicidal properties in adults, review of what is known about ketamine's safety in children …

Ketamine recently approved for therapy of treatment-resistant depression shows a complex
and not fully understood mechanism of action. Apart from its classical glutamatergic N …

Ketamine is a non-competitive antagonist of NMDA (N-methyl-D-aspartate) receptor, which
has been in clinical practice for over a half century. Despite recent data suggesting its …

Background Major depressive disorder is prevalent in children and adolescents and is
associated with a high degree of morbidity throughout life, with potentially devastating …

Ketamine, an N-methyl-D-aspartate receptor antagonist, is a racemic mixture of esketamine
and arketamine used to treat unipolar and bipolar depression. Preliminary reports indicate …