Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …

Background Treatment of mild-moderate Alzheimer's disease (AD) subjects (N= 119) for 52
weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates …

Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Stroke is a leading cause of mortality and severe long-term disability worldwide.
Development of effective treatment or new therapeutic strategies for ischemic stroke patients …

Stroke is a major cause of death and disability worldwide. Yet therapeutic strategies
available to treat stroke are very limited. There is an urgent need to develop novel …

A bulk of experimental evidence supports the idea that the stroke-damaged adult brain
makes an attempt to repair itself by producing new neurons also in areas where …

Cells must alter their expression profiles and morphological characteristics but also reshape
the extracellular matrix (ECM) to fulfill their functions throughout their lifespan. Matrix …

Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

The maturation of young neurons is regulated by complex mechanisms and dysregulation of
this process is frequently found in neurodevepmental disorders. MicroRNAs have been …