The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

Successful cell proliferation requires efficient and precise genome duplication followed by
accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is …

The YAP and TAZ paralogs are transcriptional co-activators recruited to target sites by TEAD
proteins. Here, we show that YAP and TAZ are also recruited by JUNB (a member of the AP …

Methods: HBO1 expression was tested in human OS tissues and cells. Genetic strategies,
including shRNA, CRISPR/Cas9 and overexpression constructs, were applied to …

We examined the expression and the potential biological function of HBO1 in non-small cell
lung cancer (NSCLC). TCGA and Oncomine databases showed that HBO1 transcripts were …

Although gemcitabine is the standard chemotherapeutic drug for treatment of pancreatic
cancer, almost all patients eventually develop resistance to this agent. Previous studies …

HBO1 complexes are major acetyltransferase responsible for histone H4 acetylation in vivo,
which belongs to the MYST family. As the core catalytic subunit, HBO1 consists of an N …

It has been reported that some of the food additives may cause sensitization, inflammation of
tissues, and potentially risk factors in the development of several chronic diseases. Thus, we …

The prognosis and overall survival of castration-resistant prostate cancer (CRPC) patients
are poor. The search for novel and efficient anti-CRPC agents is therefore extremely …

Mammalian chromosome duplication progresses in a precise order and is subject to
constraints that are often relaxed in developmental disorders and malignancies. Molecular …