[HTML][HTML] Mechanics in the nervous system: From development to disease
Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …
This review highlights the significance of mechanical forces in nervous system development …
[HTML][HTML] Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering development
Peripheral nerve injury (PNI) caused by trauma, chronic disease and other factors may lead
to partial or complete loss of sensory, motor and autonomic functions, as well as neuropathic …
to partial or complete loss of sensory, motor and autonomic functions, as well as neuropathic …
[HTML][HTML] Ginsenoside Rg1 ameliorates blood–brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release
K Zhai, H Duan, W Wang, S Zhao, GJ Khan… - … Pharmaceutica Sinica B, 2021 - Elsevier
During the traumatic brain injury (TBI), improved expression of circulatory miR-21 serves as
a diagnostic feature. Low levels of exosome-miR-21 in the brain can effectively improve …
a diagnostic feature. Low levels of exosome-miR-21 in the brain can effectively improve …
[HTML][HTML] Axon growth of CNS neurons in three dimensions is amoeboid and independent of adhesions
TE Santos, B Schaffran, N Broguière, L Meyn… - Cell reports, 2020 - cell.com
During development of the central nervous system (CNS), neurons polarize and rapidly
extend their axons to assemble neuronal circuits. The growth cone leads the axon to its …
extend their axons to assemble neuronal circuits. The growth cone leads the axon to its …
Integrating chemistry and mechanics: the forces driving axon growth
K Franze - Annual review of cell and developmental biology, 2020 - annualreviews.org
The brain is our most complex organ. During development, neurons extend axons, which
may grow over long distances along well-defined pathways to connect to distant targets. Our …
may grow over long distances along well-defined pathways to connect to distant targets. Our …
Local glycolysis fuels actomyosin contraction during axonal retraction
In response to repulsive cues, axonal growth cones can quickly retract. This requires the
prompt activity of contractile actomyosin, which is formed by the non-muscle myosin II (NMII) …
prompt activity of contractile actomyosin, which is formed by the non-muscle myosin II (NMII) …
Advantages of mesenchymal stem cell over the other stem cells
J Gopalarethinam, AP Nair, M Iyer, B Vellingiri… - Acta …, 2023 - Elsevier
A stem cell is a particular group of cells that has the extraordinary potential to convert within
the body into particular cell types. They are used to regenerate tissues and cells in the body …
the body into particular cell types. They are used to regenerate tissues and cells in the body …
Membrane tension propagation couples axon growth and collateral branching
Neuronal axons must navigate a mechanically heterogeneous environment to reach their
targets, but the biophysical mechanisms coupling mechanosensation, growth, and …
targets, but the biophysical mechanisms coupling mechanosensation, growth, and …
Mathematical models of neuronal growth
The establishment of a functioning neuronal network is a crucial step in neural development.
During this process, neurons extend neurites—axons and dendrites—to meet other neurons …
During this process, neurons extend neurites—axons and dendrites—to meet other neurons …
Extremely low forces induce extreme axon growth
Stretch-growth has been defined as a process that extends axons via the application of
mechanical forces. In the present article, we used a protocol based on magnetic …
mechanical forces. In the present article, we used a protocol based on magnetic …