Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However …

Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …

Genome-wide profiling of histone modifications can reveal not only the location and activity
state of regulatory elements, but also the regulatory mechanisms involved in cell-type …

Summary cis-regulatory elements (CREs) encode the genomic blueprints of spatiotemporal
gene expression programs enabling highly specialized cell functions. Using single-cell …

Regulation of hematopoiesis during human development remains poorly defined. Here we
applied single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase …

Single-cell sequencing is a powerful approach that can detect genetic alterations and their
phenotypic consequences in the context of human development, with cellular resolution …

To separate causal effects of histone acetylation on chromatin accessibility and
transcriptional output, we used integrated epigenomic and transcriptomic analyses following …

Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we
present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single …