Pluripotent stem cells (PSCs) are a potential replacement tissue source for degenerative
diseases. Age-related macular degeneration (AMD) is a blinding disease triggered by …

Human pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced
pluripotent stem cells (iPSCs), provide a dynamic tool for revealing early embryonic …

Considerable progress has been made in testing stem cell–derived retinal pigment
epithelium (RPE) as a potential therapy for age-related macular degeneration (AMD) …

This study was designed to determine whether adult mouse induced pluripotent stem cells
(iPSCs), could be used to produce retinal precursors and subsequently photoreceptor cells …

Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies,
including Leber congenital amaurosis (LCA) and Joubert-syndrome and related disorders …

Purpose: We generate a renewable supply of corneal endothelial cells (CEC) from human
pluripotent stem cells (PSCs) under defined culture conditions. Methods: Corneal …

Purpose.: Human embryonic stem cell–derived RPE (hES-RPE) transplantation is a
promising therapy for atrophic age-related macular degeneration (AMD); however, future …

Aim To generate human embryonic stem cell derived corneal endothelial cells (hESC-
CECs) for transplantation in patients with corneal endothelial dystrophies. Materials and …

Biomedical advances in vision research have been greatly facilitated by the clinical
accessibility of the visual system, its ease of experimental manipulation, and its ability to be …

Retinal degenerative diseases are the leading cause of irreversible vision loss in developed
countries. In many cases the diseases originate in the homeostatic unit in the back of the eye …