Antimicrobial resistance (AMR) has become a major problem in public health leading to an
estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and …

The metabolism of a bacterial cell stretches beyond its boundaries, often connecting with the
metabolism of other cells to form extended metabolic networks that stretch across …

The widespread utilization of tetracyclines (TCs) in agriculture and medicine has led to the
borderless spread of tetracycline resistance in humans, animals, and the environment …

Highlights•Adjuvants potentiate existing antibiotics or combat mechanisms of
resistance.•Probes enable the identification of enzymes that modify tuberculosis …

Antimicrobial resistance is a global problem, rendering conventional treatments less
effective and requiring innovative strategies to combat this growing threat. The tripartite …

Gram-negative bacteria are intrinsically resistant to many antibiotics, due in large part to the
permeability barrier formed by their cell envelope. The complex and synergistic interplay of …

Gram-negative bacterial members of the Resistance Nodulation and cell Division (RND)
superfamily form tripartite efflux pump systems that span the cell envelope. One of the …

The misuse of antibiotics has led to increased bacterial resistance, posing a global public
health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most …

Molecular tools for optogenetic control allow for spatial and temporal regulation of cell
behavior. In particular, light-controlled protein degradation is a valuable mechanism of …

Antibiotic tolerant bacteria and persistent cells that remain alive after a course of antibiotic
treatment can foster the chronicity of infections and the development of antibiotic resistance …