Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

Further considerations on how to improve phage therapy experimentation, practice, and reporting: Pharmacodynamics perspectives

ST Abedon - Therapy, Applications, and Research, 2022 - liebertpub.com
Phage therapy uses bacterial viruses (bacteriophages) to infect and kill targeted pathogens.
Approximately one decade ago, I started publishing on how possibly to improve upon phage …

Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University

S Würstle, A Lee, KE Kortright, F Winzig, W An… - Scientific Reports, 2024 - nature.com
Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent
bacterial infections, and the year 2021 marked the centennial of Felix d'Hérelle's first …

Personalized Inhaled Bacteriophage Therapy Decreases Multidrug-Resistant Pseudomonas aeruginosa

BK Chan, GL Stanley, KE Kortright, M Modak, IM Ott… - MedRxiv, 2023 - medrxiv.org
Bacteriophage therapy, which uses lytic viruses as antimicrobials, has received renewed
interest to address the emerging antimicrobial resistance (AMR) crisis. Cystic fibrosis (CF), a …

Recent Progress in Phage‐Based Nanoplatforms for Tumor Therapy

XT Li, SY Peng, SM Feng, TY Bao, SZ Li, SY Li - Small, 2024 - Wiley Online Library
Nanodrug delivery systems have demonstrated a great potential for tumor therapy with the
development of nanotechnology. Nonetheless, traditional drug delivery systems are faced …

Does Phage Therapy Need a Pan-Phage?

P Bozidis, E Markou, A Gouni, K Gartzonika - Pathogens, 2024 - mdpi.com
The emergence of multidrug-resistant bacteria is undoubtedly one of the most serious global
health threats. One response to this threat that has been gaining momentum over the past …

More evolvable bacteriophages better suppress their host

EK Horwitz, HM Strobel, J Haiso… - Evolutionary …, 2024 - Wiley Online Library
The number of multidrug‐resistant strains of bacteria is increasing rapidly, while the number
of new antibiotic discoveries has stagnated. This trend has caused a surge in interest in …

Phage cocktail superimposed disinfection: A ecological strategy for preventing pathogenic bacterial infections in dairy farms

Y Xue, Y Gao, M Guo, Y Zhang, G Zhao, L Xia… - Environmental …, 2024 - Elsevier
Bovine mastitis (BM) is mainly caused by bacterial infection that has a highly impact on dairy
production, affecting both economic viability and animal well-being. A cross-sectional study …

Phage therapy: resurrecting a historical solution for the contemporary challenge of rising antibiotic resistance in Latin America

J Yeager, AM Gómez-Jaramillo… - Expert Review of Anti …, 2024 - Taylor & Francis
ABSTRACT Introduction Antimicrobial resistance in Latin America is a growing concern in
both human and non-human animal populations. The economic burden that is likely to be …

" This training is bound for glory": selection by experimental evolution of a bacteriophage with expanded host-range and increased virulence

A Maurin, M Vasse, C Zarate-Chaves, C Breyton… - bioRxiv, 2024 - biorxiv.org
Phage host-range expansion is predicted to be at the cost of lower mean fitness. We aimed
at following the adaptive walks of a virulent phage (Tequintavirus) evolving in a spatially …