Malaria remains one of the leading causes of death worldwide, despite decades of public
health efforts. The recent commitment by many endemic countries to eliminate malaria …

A mosquito needs to ingest at least one male and one female gametocyte to become
infected with malaria. The sex of Plasmodium falciparum gametocytes can be determined …

Background Single low-dose primaquine (PQ) reduces Plasmodium falciparum infectivity
before it impacts gametocyte density. Here, we examined the effect of PQ on gametocyte sex …

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in
falciparum malaria include measurement of the duration of gametocytaemia, the rate of …

Malaria parasites exhibit a complex lifecycle, requiring extensive asexual replication in the
liver and blood of the vertebrate host, and in the haemocoel of the insect vector. Yet, they …

While significant advances have been made in understanding Plasmodium falciparum
gametocyte biology and its relationship with malaria parasite transmission, the gametocyte …

Abstract In Bandiagara, Mali, children experience on average two clinical malaria episodes
per year. However, even in the same transmission area, the number of uncomplicated …

While significant advances have been made in the prevention and treatment of malaria in
recent years, these successes continue to fall short of the World Health Organization (WHO) …

Background Primaquine (PQ) is the only currently licensed antimalarial that prevents
Plasmodium vivax (Pv) relapses. It also clears mature P. falciparum (Pf) gametocytes …

Anaemia in falciparum malaria is associated with an increased risk of gametocyte carriage,
but its effects on transmission have not been extensively evaluated in malarious children …