Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

[HTML][HTML] Oxidative stress: pathogenetic role in diabetes mellitus and its complications and therapeutic approaches to correction

MA Darenskaya, LI Kolesnikova… - Bulletin of experimental …, 2021 - Springer
The review presents modern views about the role of oxidative stress reactions in the
pathogenesis of types 1 and 2 diabetes mellitus and their complications based on the …

Molecular mechanisms linking oxidative stress and diabetes mellitus

H Yaribeygi, T Sathyapalan, SL Atkin… - … medicine and cellular …, 2020 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by
chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral …

Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments

MA Elafros, H Andersen, DL Bennett… - The Lancet …, 2022 - thelancet.com
Diabetic peripheral neuropathy (DPN) occurs in up to half of individuals with type 1 or type 2
diabetes. DPN results from the distal-to-proximal loss of peripheral nerve function, leading to …

[HTML][HTML] Antioxidant and oxidative stress: a mutual interplay in age-related diseases

BL Tan, ME Norhaizan, WPP Liew… - Frontiers in …, 2018 - frontiersin.org
Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …

[HTML][HTML] Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders

MG Rahbardar, H Hosseinzadeh - Iranian journal of basic medical …, 2020 - ncbi.nlm.nih.gov
Rosemary (Rosmarinus officinalis L.) is an evergreen bushy shrub which grows along the
Mediterranean Sea, and sub-Himalayan areas. In folk medicine, it has been used as an …

Oxidative stress as the main target in diabetic retinopathy pathophysiology

OM Cecilia, CG José Alberto, NP José… - Journal of diabetes …, 2019 - Wiley Online Library
Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus
(DM) causing vision impairment even at young ages. There are numerous mechanisms …

Diabetic neuropathy

E Zakin, R Abrams, DM Simpson - Seminars in neurology, 2019 - thieme-connect.com
Diabetes mellitus is becoming increasingly common worldwide. As this occurs, there will be
an increase in the prevalence of known comorbidities from this disorder of glucose …

Sulforaphane activates a lysosome-dependent transcriptional program to mitigate oxidative stress

D Li, R Shao, N Wang, N Zhou, K Du, J Shi, Y Wang… - Autophagy, 2021 - Taylor & Francis
Oxidative stress underlies a number of pathological conditions, including cancer,
neurodegeneration, and aging. Antioxidant-rich foods help maintain cellular redox …

Role of the ERO1-PDI interaction in oxidative protein folding and disease

AG Shergalis, S Hu, A Bankhead III… - Pharmacology & …, 2020 - Elsevier
Protein folding in the endoplasmic reticulum is an oxidative process that relies on protein
disulfide isomerase (PDI) and endoplasmic reticulum oxidase 1 (ERO1). Over 30% of …