MicroRNAs as new biomarkers for diagnosis and prognosis, and as potential therapeutic targets in acute myeloid leukemia
Acute myeloid leukemias (AML) are clonal disorders of hematopoietic progenitor cells which
are characterized by relevant heterogeneity in terms of phenotypic, genotypic, and clinical …
are characterized by relevant heterogeneity in terms of phenotypic, genotypic, and clinical …
CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome
F Taube, JA Georgi, M Kramer, S Stasik… - Blood, The Journal …, 2022 - ashpublications.org
Biallelic mutations of the CEBPA gene (CEBPA bi) define a distinct entity associated with
favorable prognosis; however, the role of monoallelic mutations (CEBPA sm) is poorly …
favorable prognosis; however, the role of monoallelic mutations (CEBPA sm) is poorly …
C/EBPα deregulation as a paradigm for leukemogenesis
JA Pulikkan, DG Tenen, G Behre - Leukemia, 2017 - nature.com
Myeloid master regulator CCAAT enhancer-binding protein alpha (C/EBPα) is deregulated
by multiple mechanisms in leukemia. Inhibition of C/EBPα function plays pivotal roles in …
by multiple mechanisms in leukemia. Inhibition of C/EBPα function plays pivotal roles in …
[HTML][HTML] DNA hypermethylation-induced miR-182 silence targets BCL2 and HOXA9 to facilitate the self-renewal of leukemia stem cell, accelerate acute myeloid …
S Ye, F Xiong, X He, Y Yuan, D Li, D Ye, L Shi, Z Lin… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: microRNAs (miRNAs) are frequently deregulated and play important roles in the
pathogenesis and progression of acute myeloid leukemia (AML). miR-182 functions as an …
pathogenesis and progression of acute myeloid leukemia (AML). miR-182 functions as an …
[HTML][HTML] Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivity
AA Wurm, S Brilloff, S Kolovich, S Schäfer… - Cell Reports …, 2023 - cell.com
Targeted therapies are effective in treating cancer, but success depends on identifying
cancer vulnerabilities. In our study, we utilize small RNA sequencing to examine the impact …
cancer vulnerabilities. In our study, we utilize small RNA sequencing to examine the impact …
The miR-183/96/182 cluster is a checkpoint for resident immune cells and shapes the cellular landscape of the cornea
Abstract Purpose The conserved miR-183/96/182 cluster (miR-183C) regulates both corneal
sensory innervation and corneal resident immune cells (CRICs). This study is to uncover its …
sensory innervation and corneal resident immune cells (CRICs). This study is to uncover its …
Low-activity programming of the PDGFRβ/FAK pathway mediates H-type vessel dysplasia and high susceptibility to osteoporosis in female offspring rats after prenatal …
Y Shangguan, Z Wu, X Xie, S Zhou, H He… - Biochemical …, 2021 - Elsevier
Dexamethasone is a common synthetic glucocorticoid drug that can promote foetal lung
maturity. An increasing number of studies have shown that prenatal dexamethasone …
maturity. An increasing number of studies have shown that prenatal dexamethasone …
[HTML][HTML] A novel circular RNA (hsa_circ_0000370) increases cell viability and inhibits apoptosis of FLT3-ITD-positive acute myeloid leukemia cells by regulating miR …
L Zhang, Z Bu, J Shen, L Shang, Y Chen… - Biomedicine & …, 2020 - Elsevier
FLT3-ITD+ acute myeloid leukemia (AML) is an important subtype of AML, accounting for
approximately 25% of all AML cases in the world. Recently, increasing evidence has shown …
approximately 25% of all AML cases in the world. Recently, increasing evidence has shown …
[HTML][HTML] miR-144 mediates high fat–induced changes of cholesterol metabolism via direct regulation of C/EBPα in the liver and isolated hepatocytes of yellow catfish
Abstract Background: microRNAs (miRNAs) post-transcriptionally regulate gene expression
and act as important modulators of cholesterol homeostasis. Objectives: The study explores …
and act as important modulators of cholesterol homeostasis. Objectives: The study explores …
The miR-183/96/182 Cluster Regulates Macrophage Functions in Response to Pseudomonas aeruginosa
CK Muraleedharan, SA McClellan… - Journal of innate …, 2019 - karger.com
Macrophages (Mϕ) are an important component of the innate immune system; they play
critical roles in the first line of defense to pathogen invasion and modulate adaptive …
critical roles in the first line of defense to pathogen invasion and modulate adaptive …