Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases

MK Skytthe, JH Graversen, SK Moestrup - International journal of …, 2020 - mdpi.com
The macrophage is a key cell in the pro-and anti-inflammatory response including that of the
inflammatory microenvironment of malignant tumors. Much current drug development in …

Monocytes and macrophages in pregnancy: The good, the bad, and the ugly

H True, M Blanton, S Sureshchandra… - Immunological …, 2022 - Wiley Online Library
A successful human pregnancy requires precisely timed adaptations by the maternal
immune system to support fetal growth while simultaneously protecting mother and fetus …

Gestational diabetes mellitus and maternal immune dysregulation: what we know so far

CJ McElwain, FP McCarthy, CM McCarthy - International Journal of …, 2021 - mdpi.com
Gestational diabetes mellitus (GDM) is an obstetric complication that affects approximately 5–
10% of all pregnancies worldwide. GDM is defined as any degree of glucose intolerance …

Transcriptomic profiling of human placenta in gestational diabetes mellitus at the single-cell level

Y Yang, F Guo, Y Peng, R Chen, W Zhou… - Frontiers in …, 2021 - frontiersin.org
Gestational diabetes mellitus (GDM) is associated with an increased risk of adverse
pregnancy outcomes. Increasing evidence shows that placentation defects may play …

Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota

V Mercado-Evans, ME Mejia, JJ Zulk, S Ottinger… - Nature …, 2024 - nature.com
Abstract Group B Streptococcus (GBS) is a pervasive perinatal pathogen, yet factors driving
GBS dissemination in utero are poorly defined. Gestational diabetes mellitus (GDM), a …

The placentas of women who suffer an episode of psychosis during pregnancy have increased lipid peroxidation with evidence of ferroptosis

MA Ortega, O Fraile-Martinez, C García-Montero… - Biomolecules, 2023 - mdpi.com
Psychosis is a complex entity characterized by psychological, behavioral, and motor
alterations resulting in a loss of contact with reality. Although it is not common, pregnancy …

The diagnostic indicators of gestational diabetes mellitus from second trimester to birth: a systematic review

D Di Filippo, T Wanniarachchi, D Wei, JJ Yang… - Clinical Diabetes and …, 2021 - Springer
Background Gestational diabetes mellitus (GDM) is glucose intolerance first recognised
during pregnancy. Both modalities and thresholds of the GDM diagnostic test, the Oral …

A Late Pleistocene coastal ecosystem in French Guiana was hyperdiverse relative to today

PO Antoine, LN Wieringa, S Adnet… - Proceedings of the …, 2024 - National Acad Sciences
Warmer temperatures and higher sea level than today characterized the Last Interglacial
interval [Pleistocene, 128 to 116 thousand years ago (ka)]. This period is a remarkable deep …

Decreased monocyte count is associated with gestational diabetes mellitus development, macrosomia, and inflammation

X Huang, B Zha, M Zhang, Y Li, Y Wu… - The Journal of …, 2022 - academic.oup.com
Context The immune system plays a central role in the pathophysiology of gestational
diabetes mellitus (GDM). Monocytes, the main innate immune cells, are especially important …

[HTML][HTML] The pathologic changes of human placental macrophages in women with hyperglycemia in pregnancy

J Ning, M Zhang, D Cui, H Yang - Placenta, 2022 - Elsevier
As the most common complication of pregnancy, hyperglycemia has a profound impact on
maternal and fetal health and the long-term development of the offspring. Placental …