Trained immunity is a functional state of the innate immune response and is characterized
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …

The mitochondrial electron transport chain utilizes a series of electron transfer reactions to
generate cellular ATP through oxidative phosphorylation. A consequence of electron …

Innate immune cells play important roles in tissue injury and repair following acute
myocardial infarction (MI). Although reprogramming of macrophage metabolism has been …

Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

BACKGROUND. While mitochondria play an important role in innate immunity, the
relationship between mitochondrial dysfunction and inflammation in heart failure (HF) is …

Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …

Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet
functions. Platelet activation determines a drastic change in redox balance and in platelet …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

Neutrophils are the most abundant, short lived, and terminally differentiated leukocytes with
distinct tiers of arsenals to counter pathogens. Neutrophils were traditionally considered …

Objective Mitochondria are multifunctional life-sustaining organelles that represent a
potential intersection point between psychosocial experiences and biological stress …