A review of reverse vaccinology approaches for the development of vaccines against ticks and tick borne diseases

AE Lew-Tabor, MR Valle - Ticks and tick-borne diseases, 2016 - Elsevier
The field of reverse vaccinology developed as an outcome of the genome sequence
revolution. Following the introduction of live vaccinations in the western world by Edward …

Recent advances in tick antigen discovery and anti-tick vaccine development

MN Abbas, MA Jmel, I Mekki, I Dijkgraaf… - International Journal of …, 2023 - mdpi.com
Ticks can seriously affect human and animal health around the globe, causing significant
economic losses each year. Chemical acaricides are widely used to control ticks, which …

Strategies for new and improved vaccines against ticks and tick‐borne diseases

J de la Fuente, P Kopáček, A Lew‐Tabor… - Parasite …, 2016 - Wiley Online Library
Ticks infest a variety of animal species and transmit pathogens causing disease in both
humans and animals worldwide. Tick–host–pathogen interactions have evolved through …

Cocktail anti-tick vaccines: The unforeseen constraints and approaches toward enhanced efficacies

C Ndawula Jr, AE Tabor - Vaccines, 2020 - mdpi.com
Ticks are second to mosquitoes as vectors of disease. Ticks affect livestock industries in
Asia, Africa and Australia at~ 1.13billionUSDperannum.Forinstance,80%oftheglobalcattlepopulationisatriskofinfestati …

Cattle tick vaccines: many candidate antigens, but will a commercially viable product emerge?

FD Guerrero, RJ Miller, AAP de León - International Journal for Parasitology, 2012 - Elsevier
The cattle tick, Rhipicephalus microplus, is arguably the world's most economically important
external parasite of cattle. Sustainable cattle tick control strategies are required to maximise …

Rhipicephalus microplus: An overview of vaccine antigens against the cattle tick

DFS Pereira, HS Ribeiro, AAM Gonçalves… - Ticks and tick-borne …, 2022 - Elsevier
Rhipicephalus microplus, popularly known as the cattle tick, is the most important tick of
livestock as it is responsible for significant economic losses. The use of chemical acaricides …

Understanding tick biology and its implications in anti-tick and transmission blocking vaccines against tick-borne pathogens

B Bhowmick, Q Han - Frontiers in Veterinary Science, 2020 - frontiersin.org
Ticks are obligate blood-feeding ectoparasites that transmit a wide variety of pathogens to
animals and humans in many parts of the world. Currently, tick control methods primarily rely …

Metazoan parasite vaccines: present status and future prospects

C Stutzer, SA Richards, M Ferreira, S Baron… - Frontiers in cellular …, 2018 - frontiersin.org
Eukaryotic parasites and pathogens continue to cause some of the most detrimental and
difficult to treat diseases (or disease states) in both humans and animals, while also …

The quest for a universal vaccine against ticks: cross-immunity insights

LF Parizi, NW Githaka, C Logullo, S Konnai… - The Veterinary …, 2012 - Elsevier
As blood-sucking parasites, ticks inflict great damage to animals and humans in many parts
of the world. The continued use of chemical acaricides is not sustainable due to increasing …

ABC transporter efflux pumps: a defense mechanism against ivermectin in Rhipicephalus (Boophilus) microplus

PC Pohl, GM Klafke, DD Carvalho, JR Martins… - International journal for …, 2011 - Elsevier
ATP-binding cassette (ABC) transporters are efflux transporters found in all organisms.
These proteins are responsible for pumping xenobiotic and endogenous metabolites …