Biomedical importance of indoles

NK Kaushik, N Kaushik, P Attri, N Kumar, CH Kim… - Molecules, 2013 - mdpi.com
The indole nucleus is an important element of many natural and synthetic molecules with
significant biological activity. This review covers some of the relevant and recent …

A brief review of the biological potential of indole derivatives

S Kumar, Ritika - Future Journal of Pharmaceutical Sciences, 2020 - Springer
Background Various bioactive aromatic compounds containing the indole nucleus showed
clinical and biological applications. Indole scaffold has been found in many of the important …

The chemistry of heterocycles in the 21st century

VN Charushin, EV Verbitskiy, ON Chupakhin… - Uspekhi Khimii, 2024 - mathnet.ru
The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

Antioxidant activities of synthetic indole derivatives and possible activity mechanisms

S Süzen - Bioactive heterocycles V, 2007 - Springer
Indole derivatives constitute an important class of therapeutical agents in medicinal
chemistry including anticancer, antioxidant, antirheumatoidal, aldose reductase inhibitor …

Synthesis, characterization and antibacterial activity of cobalt (III) complexes with pyridine–amide ligands

A Mishra, NK Kaushik, AK Verma, R Gupta - European journal of medicinal …, 2008 - Elsevier
The ligands 2-(N-(X-pyridyl) carbamoyl) pyridine (X= 2, 3 or 4 for HL1–HL3, respectively)
and 2, 6-bis (N-(Y-pyridyl) carbamoyl) pyridine (Y= 2, 3 or 4 for H2L4–H2L6, respectively) in …

An efficient synthesis of bis (indolyl) methanes and evaluation of their antimicrobial activities

A Kamal, MNA Khan, K Srinivasa Reddy… - Journal of enzyme …, 2009 - Taylor & Francis
A versatile and efficient method has been developed for the synthesis of bis (indolyl)
methanes by using aluminium triflate (0.5 mol%) as a novel catalyst. Further, some of the …

Benzotriazole: an excellent ligand for Cu-catalyzed N-arylation of imidazoles with aryl and heteroaryl halides

AK Verma, J Singh, VK Sankar, R Chaudhary… - Tetrahedron letters, 2007 - Elsevier
Benzotriazole (BtH) is an efficient ligand for the Cu-catalyzed N-arylation of imidazoles with
aryl and heteroaryl halides. A combination of CuI/BtH was found to be an efficient and …

Synthesis, spectral, crystal structure and in vitro antimicrobial evaluation of imidazole/benzotriazole substituted piperidin-4-one derivatives

R Ramachandran, M Rani, S Senthan, YT Jeong… - European journal of …, 2011 - Elsevier
Imidazole/benzotriazole analogues substituted piperidin-4-one derivatives (17–26) have
been synthesized. Their chemical structures were characterized by IR, 1H NMR, 13C NMR …

Synthesis and Biological Activities of Pyrazino[1,2-a]indole and Pyrazino[1,2-a]indol-1-one Derivatives

K Zhang, C Tran, M Alami, A Hamze, O Provot - Pharmaceuticals, 2021 - mdpi.com
This review concerns the synthesis and biological activities of pyrazino [1, 2-a] indoles and
pyrazino [1, 2-a] indol-1-ones reported since 1997 and the discovery of biological activity of …

Microwave-assisted synthesis of 3′-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity

HG Kathrotiya, MP Patel - Medicinal Chemistry Research, 2012 - Springer
A new series of indole-based chromene derivatives 4a–4p has been synthesized by one pot
cyclocondensation reaction of 2-phenyl-1 H-indole-3-carbaldehyde 1a–1h; malononitrile 2; …