Immune checkpoint blockade (ICB) therapies have achieved clinical benefit, but most
'immune-cold'solid tumors are not responsive. The diversity of immune evasion mechanisms …

Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …

Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

The balance of programmed death-1 (PD-1)-expressing CD8+ T cells and regulatory T
(Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 …

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major
barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the …

CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

Mapping tumor metabolic remodeling and their spatial crosstalk with surrounding non-tumor
cells can fundamentally improve our understanding of tumor biology, facilitates the …

Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …