Gut microbiota-derived metabolites as key actors in inflammatory bowel disease
A key role of the gut microbiota in the establishment and maintenance of health, as well as in
the pathogenesis of disease, has been identified over the past two decades. One of the …
the pathogenesis of disease, has been identified over the past two decades. One of the …
Molecular physiology of bile acid signaling in health, disease, and aging
A Perino, H Demagny… - Physiological …, 2021 - journals.physiology.org
Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin
L Sun, C Xie, G Wang, Y Wu, Q Wu, X Wang, J Liu… - Nature medicine, 2018 - nature.com
The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on
signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently …
signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently …
Targeting the alternative bile acid synthetic pathway for metabolic diseases
W Jia, M Wei, C Rajani, X Zheng - Protein & cell, 2021 - academic.oup.com
The gut microbiota is profoundly involved in glucose and lipid metabolism, in part by
regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways …
regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways …
Bile acids and their receptors in metabolic disorders
Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
Primary biliary cholangitis: pathogenesis and therapeutic opportunities
AF Gulamhusein, GM Hirschfield - Nature Reviews Gastroenterology & …, 2020 - nature.com
Primary biliary cholangitis is a chronic, seropositive and female-predominant inflammatory
and cholestatic liver disease, which has a variable rate of progression towards biliary …
and cholestatic liver disease, which has a variable rate of progression towards biliary …
Intestinal Microbiota in Cardiovascular Health and Disease: JACC State-of-the-Art Review
WHW Tang, F Bäckhed, U Landmesser… - Journal of the American …, 2019 - jacc.org
Despite major strides in reducing cardiovascular disease (CVD) burden with modification of
classic CVD risk factors, significant residual risks remain. Recent discoveries that linked …
classic CVD risk factors, significant residual risks remain. Recent discoveries that linked …
Bile acids in glucose metabolism and insulin signalling—mechanisms and research needs
TR Ahmad, RA Haeusler - Nature Reviews Endocrinology, 2019 - nature.com
Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs)
are notable for the fact that they were hiding in plain sight. BAs were well known for their …
are notable for the fact that they were hiding in plain sight. BAs were well known for their …
Discovery of farnesoid X receptor and its role in bile acid metabolism
JYL Chiang, JM Ferrell - Molecular and cellular endocrinology, 2022 - Elsevier
In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …
[HTML][HTML] Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal
L Chen, T Jiao, W Liu, Y Luo, J Wang, X Guo, X Tong… - Cell Stem Cell, 2022 - cell.com
Although disrupted bile acid (BA) homeostasis is implicated in inflammatory bowel disease
(IBD), the role of hepatic BA metabolism in the pathogenesis of colitis is poorly understood …
(IBD), the role of hepatic BA metabolism in the pathogenesis of colitis is poorly understood …