A key role of the gut microbiota in the establishment and maintenance of health, as well as in
the pathogenesis of disease, has been identified over the past two decades. One of the …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on
signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently …

The gut microbiota is profoundly involved in glucose and lipid metabolism, in part by
regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways …

Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

Primary biliary cholangitis is a chronic, seropositive and female-predominant inflammatory
and cholestatic liver disease, which has a variable rate of progression towards biliary …

Despite major strides in reducing cardiovascular disease (CVD) burden with modification of
classic CVD risk factors, significant residual risks remain. Recent discoveries that linked …

Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs)
are notable for the fact that they were hiding in plain sight. BAs were well known for their …

In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …

Although disrupted bile acid (BA) homeostasis is implicated in inflammatory bowel disease
(IBD), the role of hepatic BA metabolism in the pathogenesis of colitis is poorly understood …