Gram-negative bacteria and their complex cell envelope, which comprises an outer
membrane and an inner membrane, are an important and attractive system for studying the …

Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly
common and are causing a global health crisis. Antibiotic resistance is encoded by several …

In 2008, a previously unknown Escherichia coli clonal group, sequence type 131 (ST131),
was identified on three continents. Today, ST131 is the predominant E. coli lineage among …

Antimicrobial-resistant Klebsiella pneumoniae (Kp) has emerged as a major global public
health problem. While resistance can occur across a broad range of Kp clones, a small …

Objectives Whole-genome sequencing potentially represents a single, rapid and cost-
effective approach to defining resistance mechanisms and predicting phenotype, and strain …

Quick, simple, and reliable methods are needed for laboratory detection of carbapenemases
that are widely disseminated among Gram-negative bacteria, in order to improve the …

Carbapenem-resistant Enterobacteriaceae (CRE) are among the most severe threats to the
antibiotic era. Multiple different species can exhibit resistance due to many different …

Background: Antimicrobial resistance (AMR) has posed a serious threat to global public
health and it requires immediate action, preferably long term. Current drug therapies have …

1. Executive summary Multi-drug-resistant (MDR) Gram-negative bacterial infections have
become prevalent in some European countries. Moreover, increased use of broad-spectrum …

The aim of this study was to characterize by a multi-level approach extended-spectrum β-
lactamase (ESBL)-producing Enterobacteriaceae isolates other than E. coli from Portuguese …