Pathogenesis of Helicobacter pylori infection

M Chmiela, J Kupcinskas - Helicobacter, 2019 - Wiley Online Library
In this review, we shall focus on the last year progression understanding the pathogenesis of
Helicobacter pylori infection in the light of recent data related to adaptation of H pylori to the …

Role of the DNA-binding protein pA104R in ASFV genome packaging and as a novel target for vaccine and drug development

AC Urbano, F Ferreira - Vaccines, 2020 - mdpi.com
The recent incursions of African swine fever (ASF), a severe, highly contagious,
transboundary viral disease that affects members of the Suidae family, in Europe and China …

Epigallocatechin Gallate with Potent Anti-Helicobacter pylori Activity Binds Efficiently to Its Histone-like DNA Binding Protein

R Raj, N Agarwal, S Raghavan, T Chakraborti… - ACS …, 2021 - ACS Publications
Helicobacter pylori (H. pylori)—a human gastric pathogen—forms a major risk factor for the
development of various gastric pathologies such as chronic inflammatory gastritis, peptic …

ROS-mediated up-regulation of SAE1 by Helicobacter pylori promotes human gastric tumor genesis and progression

L Shi, J Shangguan, Y Lu, J Rong, Q Yang… - Journal of Translational …, 2024 - Springer
Helicobacter pylori (H. pylori) is a major risk factor of gastric cancer (GC). The SUMO-
activating enzyme SAE1 (SUMO-activating enzyme subunit 1), which is indispensable for …

Exquisite binding interaction of 18β-Glycyrrhetinic acid with histone like DNA binding protein of Helicobacter pylori: A computational and experimental study

R Raj, N Agarwal, S Raghavan, T Chakraborti… - International Journal of …, 2020 - Elsevier
The Histone-like DNA binding protein is one of the most abundant nucleoid associated
protein expressed by human gastric-pathogen, Helicobacter pylori (H. pylori). The protein …

Molecular Insights into Conformational Heterogeneity and Enhanced Structural Integrity of Helicobacter pylori DNA Binding Protein Hup at Low pH

N Agarwal, N Jaiswal, K Gulati, K Gangele, N Nagar… - Biochemistry, 2021 - ACS Publications
The summarized amalgam of internal relaxation modulations and external forces like pH,
temperature, and solvent conditions determine the protein structure, stability, and function. In …

Elucidating protein-ligand interactions using high throughput biophysical techniques

N Agarwal, V Chetry, KM Poluri - Innovations and Implementations of …, 2021 - Springer
Proteins are large, complex molecules that functionally regulates almost all cellular and
biochemical processes. As proteins are important component in cell physiology, their …

Pesticide interactions induce alterations in secondary structure of malate dehydrogenase to cause destability and cytotoxicity

S Devi, K Karsauliya, T Srivastava, R Raj, D Kumar… - Chemosphere, 2021 - Elsevier
Environmental exposure to pesticides increases the risk of neurotoxicity and
neurodegenerative diseases. The mechanism of pesticide-induced toxicity is attributed to …

Conserved Apical Proline Regulating the Structure and DNA Binding Properties of Helicobacter pylori Histone-like DNA Binding Protein (Hup)

N Agarwal, N Nagar, R Raj, D Kumar, KM Poluri - ACS omega, 2022 - ACS Publications
Prokaryotic cells lack a proper dedicated nuclear arrangement machinery. A set of proteins
known as nucleoid associated proteins (NAPs) perform opening and closure of nucleic …

CARD9 protein SUMOylation regulates HOXB5 nuclear translocation and Parkin‐mediated mitophagy in myocardial I/R injury

Y Li, Y Tang, X Yan, H Lin, W Jiang… - Journal of Cellular …, 2024 - Wiley Online Library
Myocardial injury induced by ischemia–reperfusion (I/R) remains a difficult clinical problem.
However, the exact mechanisms underlying I/R‐induced have yet to be clarified. CARD9 is …