Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …

Shuttling of specific proteins out of the nucleus is essential for the regulation of the cell cycle
and proliferation of both normal and malignant tissues. Dysregulation of this fundamental …

Acute myeloid leukemia (AML) is a heterogeneous disease with variable patient responses
to therapy. Selinexor, an inhibitor of nuclear export, has shown promising clinical activity for …

Multiple myeloma (MM) is a malignancy of plasma cells that is typically chronic, and relapse
is common. Current therapeutic strategies include combination and sequential treatments …

The transport of proteins across the nuclear membrane is a highly regulated process,
essential for the cell function. This transport is actively mediated by members of the …

CRM1 or XPO1 is the major nuclear export receptor in the cell, which controls the nuclear-
cytoplasmic localization of many proteins and RNAs. CRM1 is also a promising cancer drug …

The nuclear export protein, exportin-1 (XPO1/CRM1), is overexpressed in many cancers and
correlates with poor prognosis. Selinexor, a first-in-class Selective Inhibitor of Nuclear Export …

The composition of the nucleoplasm determines the behavior of key processes such as
transcription, yet there is still no reliable and quantitative resource of nuclear proteins …

We present a fast and effective covalent docking approach suitable for large-scale virtual
screening (VS). We applied this method to four targets (HCV NS3 protease, Cathepsin K …

Gastrointestinal (GI) carcinomas are a group of cancers affecting the GI tract and digestive
organs, such as the gastric, liver, bile ducts, pancreas, small intestine, esophagus, colon …