Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Numerous therapeutic strategies have been described for prevention and reduction of
hypertrophic scars and keloids, but none of the treatments is effective in all patients. No …

Fibrosis is characterized by excessive deposition of extracellular matrix components such as
collagen in tissues or organs. Fibrosis can develop in the heart, kidneys, liver, skin or any …

Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

High-quality postoperative rehabilitation is the focus of most patients currently, and
hypertrophic scar (HS) greatly reduces the patient's quality of life due to the symptom of …

Keloid disorder, a group of fibroproliferative skin disorders, is clinically comprised of keloids,
hypertrophic scars, keloidalis nuchae, and acne keloidalis. The prototype of these disorders …

Cutaneous pathological scars are fibrotic lesions that grow continuously, invade the
adjacent skin, and are erythematous, itchy, and painful. Their etiology remains unclear but …

Keloids are an abnormal fibroproliferative wound-healing disease with a poorly understood
pathogenesis, making it difficult to predict and prevent this disease in clinical settings …

Hypertrophic scars (HTS) are elevated scars which occur due to abnormalities in wound
healing after injury and may be associated with pain, pruritus and functional impairment …

Since its first description around the year 2000, the local renin‐angiotensin system (RAS) in
skin has been subject of an increasing number of studies with many additions over the last …