Stimuli-responsive In situ gelling system for nose-to-brain drug delivery
The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …
research fraternity due to the presence of BBB. The intranasal route appeared as an …
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …
molecular mechanisms involved in this process, such as autophagy, may contribute to …
Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting
In last two decades, the lipid nanocarriers have been extensively investigated for their drug
targeting efficiency towards the critical areas of the human body like CNS, cardiac region …
targeting efficiency towards the critical areas of the human body like CNS, cardiac region …
Nanoemulgel: a novel nano carrier as a tool for topical drug delivery
Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic
profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes …
profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes …
[HTML][HTML] Cell models for Alzheimer's and Parkinson's disease: At the interface of biology and drug discovery
Neurodegenerative diseases are severely debilitating conditions characterized primarily by
progressive neuronal loss and impairment of the nervous system. Alzheimer's and …
progressive neuronal loss and impairment of the nervous system. Alzheimer's and …
Transferrin-modified osthole PEGylated liposomes travel the blood-brain barrier and mitigate Alzheimer's disease-related pathology in APP/PS-1 mice
L Kong, X Li, Y Ni, H Xiao, Y Yao, Y Wang… - International journal …, 2020 - Taylor & Francis
Introduction Osthole (Ost) is a coumarin compound that strengthens hippocampal neurons
and neural stem cells against Aβ oligomer-induced neurotoxicity in mice, and is a potential …
and neural stem cells against Aβ oligomer-induced neurotoxicity in mice, and is a potential …
Neuroinflammatory In Vitro Cell Culture Models and the Potential Applications for Neurological Disorders
Y Peng, S Chu, Y Yang, Z Zhang, Z Pang… - Frontiers in …, 2021 - frontiersin.org
Cell cultures are used in pharmaceutical, medical and biological sciences. Due to the ethical
and cost limitations of in vivo models, the replaceable cell model that is more closely related …
and cost limitations of in vivo models, the replaceable cell model that is more closely related …
Biomaterials in treatment of Alzheimer's disease
Alzheimer's disease (AD) is a non-recoverable progressive neurodegenerative disorder
most prevalent but not limited to the old age population. After all the scientific efforts, there …
most prevalent but not limited to the old age population. After all the scientific efforts, there …
Recent advances in Bio-conjugated nanocarriers for crossing the Blood-Brain Barrier in (pre-) clinical studies with an emphasis on vesicles
A Poustforoosh, MH Nematollahi… - Journal of Controlled …, 2022 - Elsevier
The brain is one of the most challenging organs for drug delivery. It is preserved by the
blood-brain barrier (BBB), which controls the transport of components into and out of the …
blood-brain barrier (BBB), which controls the transport of components into and out of the …
Design and biological evaluation of lipoprotein-based donepezil nanocarrier for enhanced brain uptake through oral delivery
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
memory and cognitive impairment. Donepezil is an acetylcholinesterase inhibitor used for …
memory and cognitive impairment. Donepezil is an acetylcholinesterase inhibitor used for …